論文 - 詳細
| RRC ID | 45812 |
|---|---|
| 著者 | Nagy AI, Vázquez-Manrique RP, Lopez M, Christov CP, Sequedo MD, Herzog M, Herlihy AE, Bodak M, Gatsi R, Baylis HA. |
| タイトル | IP3 signalling regulates exogenous RNAi in Caenorhabditis elegans. |
| ジャーナル | EMBO Rep |
| Abstract |
RNA interference (RNAi) is a widespread and widely exploited phenomenon. Here, we show that changing inositol 1,4,5-trisphosphate (IP3) signalling alters RNAi sensitivity in Caenorhabditis elegans. Reducing IP3 signalling enhances sensitivity to RNAi in a broad range of genes and tissues. Conversely up-regulating IP3 signalling decreases sensitivity. Tissue-specific rescue experiments suggest IP3 functions in the intestine. We also exploit IP3 signalling mutants to further enhance the sensitivity of RNAi hypersensitive strains. These results demonstrate that conserved cell signalling pathways can modify RNAi responses, implying that RNAi responses may be influenced by an animal's physiology or environment. |
| 巻・号 | 16(3) |
| ページ | 341-50 |
| 公開日 | 2015-3-1 |
| DOI | 10.15252/embr.201439585 |
| PII | embr.201439585 |
| PMID | 25608529 |
| PMC | PMC4353841 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Image Processing, Computer-Assisted Inositol 1,4,5-Trisphosphate / metabolism* Intestinal Mucosa / metabolism Microscopy, Fluorescence Models, Biological RNA Interference / physiology* RNA, Double-Stranded Signal Transduction / genetics Signal Transduction / physiology* |
| IF | 7.497 |
| 引用数 | 1 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm902 tm753 |