論文 - 詳細
| RRC ID | 45816 |
|---|---|
| 著者 | Nguyen PA, Liou W, Hall DH, Leroux MR. |
| タイトル | Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron. |
| ジャーナル | J Cell Sci |
| Abstract |
How signaling domains form is an important, yet largely unexplored question. Here, we show that ciliary proteins help establish two contiguous, yet distinct cyclic GMP (cGMP) signaling compartments in Caenorhabditis elegans thermosensory AFD neurons. One compartment, a bona fide cilium, is delineated by proteins associated with Bardet-Biedl syndrome (BBS), Meckel syndrome and nephronophthisis at its base, and requires NPHP-2 (known as inversin in mammals) to anchor a cGMP-gated ion channel within the proximal ciliary region. The other, a subcompartment with profuse microvilli and a different lipid environment, is separated from the dendrite by a cellular junction and requires BBS-8 and DAF-25 (known as Ankmy2 in mammals) for correct localization of guanylyl cyclases needed for thermosensation. Consistent with a requirement for a membrane diffusion barrier at the subcompartment base, we reveal the unexpected presence of ciliary transition zone proteins where no canonical transition zone ultrastructure exists. We propose that differential compartmentalization of signal transduction components by ciliary proteins is important for the functions of ciliated sensory neurons. |
| 巻・号 | 127(Pt 24) |
| ページ | 5317-30 |
| 公開日 | 2014-12-15 |
| DOI | 10.1242/jcs.157610 |
| PII | jcs.157610 |
| PMID | 25335890 |
| PMC | PMC4265742 |
| MeSH | Actins / metabolism Animals Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism* Cell Compartmentation* Cilia / metabolism* Cyclic GMP / metabolism Dendrites / metabolism Guanylate Cyclase / metabolism Intercellular Junctions / metabolism Intermediate Filaments / metabolism Lipids / chemistry Models, Biological Mutation / genetics Protein Transport Sensory Receptor Cells / cytology* Sensory Receptor Cells / metabolism* Signal Transduction* Temperature* Tomography |
| IF | 4.573 |
| 引用数 | 17 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3100 |