RRC ID 45822
Author Ohta A, Ujisawa T, Sonoda S, Kuhara A.
Title Light and pheromone-sensing neurons regulates cold habituation through insulin signalling in Caenorhabditis elegans.
Journal Nat Commun
Abstract Temperature is a critical environmental stimulus that has a strong impact on an organism's biochemistry. Animals can respond to changes in ambient temperature through behaviour or altered physiology. However, how animals habituate to temperature is poorly understood. The nematode C. elegans stores temperature experiences and can induce temperature habituation-linked cold tolerance. Here we show that light and pheromone-sensing neurons (ASJ) regulate cold habituation through insulin signalling. Calcium imaging reveals that ASJ neurons respond to temperature. Cold habituation is abnormal in a mutant with impaired cGMP signalling in ASJ neurons. Insulin released from ASJ neurons is received by the intestine and neurons regulating gene expression for cold habituation. Thus, temperature sensation in a light and pheromone-sensing neuron produces a robust effect on insulin signalling that controls experience-dependent temperature habituation.
Volume 5
Pages 4412
Published 2014-7-22
DOI 10.1038/ncomms5412
PII ncomms5412
PMID 25048458
PMC PMC4109018
MeSH Adaptation, Physiological Animals Animals, Genetically Modified Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Calcium / analysis Calcium / metabolism Cold Temperature Cold-Shock Response Gene Expression Regulation Insulin / metabolism* Intestinal Mucosa / metabolism Light Mutation Neurons / metabolism* Pheromones / metabolism* Signal Transduction
IF 12.121
Times Cited 36
C.elegans tm2308 tm2416 tm2418 tm2468 tm1770 tm4977 tm830 tm1013 tm3675 tm3617 tm2416 tm1093