論文 - 詳細
| RRC ID | 45843 |
|---|---|
| 著者 | Russell J, Vidal-Gadea AG, Makay A, Lanam C, Pierce-Shimomura JT. |
| タイトル | Humidity sensation requires both mechanosensory and thermosensory pathways in Caenorhabditis elegans. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
All terrestrial animals must find a proper level of moisture to ensure their health and survival. The cellular-molecular basis for sensing humidity is unknown in most animals, however. We used the model nematode Caenorhabditis elegans to uncover a mechanism for sensing humidity. We found that whereas C. elegans showed no obvious preference for humidity levels under standard culture conditions, worms displayed a strong preference after pairing starvation with different humidity levels, orienting to gradients as shallow as 0.03% relative humidity per millimeter. Cell-specific ablation and rescue experiments demonstrate that orientation to humidity in C. elegans requires the obligatory combination of distinct mechanosensitive and thermosensitive pathways. The mechanosensitive pathway requires a conserved DEG/ENaC/ASIC mechanoreceptor complex in the FLP neuron pair. Because humidity levels influence the hydration of the worm's cuticle, our results suggest that FLP may convey humidity information by reporting the degree that subcuticular dendritic sensory branches of FLP neurons are stretched by hydration. The thermosensitive pathway requires cGMP-gated channels in the AFD neuron pair. Because humidity levels affect evaporative cooling, AFD may convey humidity information by reporting thermal flux. Thus, humidity sensation arises as a metamodality in C. elegans that requires the integration of parallel mechanosensory and thermosensory pathways. This hygrosensation strategy, first proposed by Thunberg more than 100 y ago, may be conserved because the underlying pathways have cellular and molecular equivalents across a wide range of species, including insects and humans. |
| 巻・号 | 111(22) |
| ページ | 8269-74 |
| 公開日 | 2014-6-3 |
| DOI | 10.1073/pnas.1322512111 |
| PII | 1322512111 |
| PMID | 24843133 |
| PMC | PMC4050571 |
| MeSH | Acid Sensing Ion Channels / physiology Animals Behavior, Animal / physiology Caenorhabditis elegans / cytology Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / physiology Cyclic GMP / physiology Epithelial Sodium Channels / physiology Humans Humidity* Ion Channel Gating / physiology Ion Channels / physiology Mechanoreceptors / physiology* Membrane Proteins / physiology Motor Activity / physiology Multiprotein Complexes / physiology Sensory Receptor Cells / physiology* Starvation / physiopathology Thermosensing / physiology* |
| IF | 9.412 |
| 引用数 | 37 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 11 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1552 |