論文 - 詳細
| RRC ID | 45897 |
|---|---|
| 著者 | Yoshida M, Oami E, Wang M, Ishiura S, Suo S. |
| タイトル | Nonredundant function of two highly homologous octopamine receptors in food-deprivation-mediated signaling in Caenorhabditis elegans. |
| ジャーナル | J Neurosci Res |
| Abstract |
It is common for neurotransmitters to possess multiple receptors that couple to the same intracellular signaling molecules. This study analyzes two highly homologous G-protein-coupled octopamine receptors using the model animal Caenorhabditis elegans. In C. elegans, the amine neurotransmitter octopamine induces activation of cAMP response element-binding protein (CREB) in the cholinergic SIA neurons in the absence of food through activation of the Gq-coupled octopamine receptor SER-3 in these neurons. We also analyzed another Gq-coupled octopamine receptor, SER-6, that is highly homologous to SER-3. As seen in ser-3 deletion mutants, octopamine- and food-deprivation-mediated CREB activation was decreased in ser-6 deletion mutants compared with wild-type animals, suggesting that both SER-3 and SER-6 are required for signal transduction. Cell-specific expression of SER-6 in the SIA neurons was sufficient to restore CREB activation in the ser-6 mutants, indicating that SER-6, like SER-3, functions in these neurons. Taken together, these results demonstrate that two similar G-protein-coupled receptors, SER-3 and SER-6, function in the same cells in a nonredundant manner. |
| 巻・号 | 92(5) |
| ページ | 671-8 |
| 公開日 | 2014-5-1 |
| DOI | 10.1002/jnr.23345 |
| PMID | 24446241 |
| MeSH | Adrenergic alpha-Agonists / pharmacology Animals Animals, Genetically Modified CREB-Binding Protein / metabolism Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics Food Deprivation / physiology* Mutation / genetics Neurons / metabolism* Octopamine / pharmacology Phylogeny Receptors, Biogenic Amine / metabolism* Receptors, Serotonin / genetics Receptors, Serotonin / metabolism* Receptors, Serotonin, 5-HT3 / genetics Receptors, Serotonin, 5-HT3 / metabolism* Transcriptome / drug effects Transcriptome / physiology* |
| IF | 4.699 |
| 引用数 | 10 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2104 tm2146 |