| RRC ID |
45901
|
| 著者 |
Zhang Y, Li W, Li L, Li Y, Fu R, Zhu Y, Li J, Zhou Y, Xiong S, Zhang H.
|
| タイトル |
Structural damage in the C. elegans epidermis causes release of STA-2 and induction of an innate immune response.
|
| ジャーナル |
Immunity
|
| Abstract |
The epidermis constantly encounters invasions that disrupt its architecture, yet whether the epidermal immune system utilizes damaged structures as danger signals to activate self-defense is unclear. Here, we used a C. elegans epidermis model in which skin-penetrating infection or injury activates immune defense and antimicrobial peptide (AMP) production. By systemically disrupting each architectural component, we found that only disturbance of the apical hemidesmosomes triggered an immune response and robust AMP expression. The epidermis recognized structural damage through hemidesmosomes associated with a STAT-like protein, whose disruption led to detachment of STA-2 molecules from hemidesmosomes and transcription of AMPs. This machinery enabled the epidermis to bypass certain signaling amplification and directly trigger AMP production when subjected to extensive architectural damage. Together, our findings uncover an evolutionarily conserved mechanism for the epithelial barriers to detect danger and activate immune defense.
|
| 巻・号 |
42(2)
|
| ページ |
309-320
|
| 公開日 |
2015-2-17
|
| DOI |
10.1016/j.immuni.2015.01.014
|
| PII |
S1074-7613(15)00040-0
|
| PMID |
25692704
|
| MeSH |
Animals
Antimicrobial Cationic Peptides / biosynthesis*
Antimicrobial Cationic Peptides / genetics
Caenorhabditis elegans / immunology*
Caenorhabditis elegans Proteins / immunology
Caenorhabditis elegans Proteins / metabolism*
Cell Adhesion Molecules / immunology
Cells, Cultured
Epidermis / immunology*
Epidermis / injuries*
Hemidesmosomes / immunology
Hemidesmosomes / pathology
Humans
Immunity, Innate
Keratinocytes / immunology
Keratinocytes / metabolism
STAT Transcription Factors / metabolism*
Signal Transduction / immunology
p38 Mitogen-Activated Protein Kinases / immunology
|
| IF |
22.553
|
| 引用数 |
26
|
|
WOS 分野
|
IMMUNOLOGY
|
| リソース情報 |
| 線虫 |
tm1962
tm3036 |
