RRC ID 45984
Author Hapiak V, Summers P, Ortega A, Law WJ, Stein A, Komuniecki R.
Title Neuropeptides amplify and focus the monoaminergic inhibition of nociception in Caenorhabditis elegans.
Journal J Neurosci
Abstract Monoamines and neuropeptides interact to modulate most behaviors. To better understand these interactions, we have defined the roles of tyramine (TA), octopamine, and neuropeptides in the inhibition of aversive behavior in Caenorhabditis elegans. TA abolishes the serotonergic sensitization of aversive behavior mediated by the two nociceptive ASH sensory neurons and requires the expression of the adrenergic-like, Gαq-coupled, TA receptor TYRA-3 on inhibitory monoaminergic and peptidergic neurons. For example, TA inhibition requires Gαq and Gαs signaling in the peptidergic ASI sensory neurons, with an array of ASI neuropeptides activating neuropeptide receptors on additional neurons involved in locomotory decision-making. The ASI neuropeptides required for tyraminergic inhibition are distinct from those required for octopaminergic inhibition, suggesting that individual monoamines stimulate the release of different subsets of ASI neuropeptides. Together, these results demonstrate that a complex humoral mix of monoamines is focused by more local, synaptic, neuropeptide release to modulate nociception and highlight the similarities between the tyraminergic/octopaminergic inhibition of nociception in C. elegans and the noradrenergic inhibition of nociception in mammals that also involves inhibitory peptidergic signaling.
Volume 33(35)
Pages 14107-16
Published 2013-8-28
DOI 10.1523/JNEUROSCI.1324-13.2013
PII 33/35/14107
PMID 23986246
PMC PMC3756756
MeSH Animals Caenorhabditis elegans Caenorhabditis elegans Proteins / antagonists & inhibitors Caenorhabditis elegans Proteins / metabolism GTP-Binding Protein alpha Subunits / metabolism Locomotion Neuropeptides / metabolism* Nociception* Octopamine / pharmacology* Receptors, Catecholamine / antagonists & inhibitors Receptors, Catecholamine / metabolism Sensory Receptor Cells / metabolism Sensory Receptor Cells / physiology Synaptic Transmission Tyramine / pharmacology*
IF 5.674
Times Cited 14
C.elegans tm1880 tm1497 tm2243 tm2984 tm3572 tm2105 tm1652 tm1765 tm1504 tm1583 tm2765 tm2974 tm3082 tm1498 tm1782 tm1553 tm1568 tm4763