論文 - 詳細
| RRC ID | 46025 |
|---|---|
| 著者 | El Bejjani R, Hammarlund M. |
| タイトル | Notch signaling inhibits axon regeneration. |
| ジャーナル | Neuron |
| Abstract |
Many neurons have limited capacity to regenerate their axons after injury. Neurons in the mammalian central nervous system do not regenerate, and even neurons in the peripheral nervous system often fail to regenerate to their former targets. This failure is likely due in part to pathways that actively restrict regeneration; however, only a few factors that limit regeneration are known. Here, using single-neuron analysis of regeneration in vivo, we show that Notch/lin-12 signaling inhibits the regeneration of mature C. elegans neurons. Notch signaling suppresses regeneration by acting autonomously in the injured cell to prevent growth cone formation. The metalloprotease and gamma-secretase cleavage events that lead to Notch activation during development are also required for its activity in regeneration. Furthermore, blocking Notch activation immediately after injury improves regeneration. Our results define a postdevelopmental role for the Notch pathway as a repressor of axon regeneration in vivo. |
| 巻・号 | 73(2) |
| ページ | 268-78 |
| 公開日 | 2012-1-26 |
| DOI | 10.1016/j.neuron.2011.11.017 |
| PII | S0896-6273(11)01092-0 |
| PMID | 22284182 |
| PMC | PMC3690129 |
| MeSH | Animals Axons / metabolism* Caenorhabditis elegans Caenorhabditis elegans Proteins / metabolism* Growth Cones / metabolism Membrane Proteins / metabolism* Nerve Regeneration / physiology* Neurons / physiology Receptors, Notch / metabolism* Recovery of Function / physiology Signal Transduction / physiology* |
| IF | 14.415 |
| 引用数 | 50 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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