論文 - 詳細
| RRC ID | 46108 |
|---|---|
| 著者 | Harris DT, Horvitz HR. |
| タイトル | MAB-10/NAB acts with LIN-29/EGR to regulate terminal differentiation and the transition from larva to adult in C. elegans. |
| ジャーナル | Development |
| Abstract |
In Caenorhabditis elegans, a well-defined pathway of heterochronic genes ensures the proper timing of stage-specific developmental events. During the final larval stage, an upregulation of the let-7 microRNA indirectly activates the terminal differentiation factor and central regulator of the larval-to-adult transition, LIN-29, via the downregulation of the let-7 target genes lin-41 and hbl-1. Here, we identify a new heterochronic gene, mab-10, and show that mab-10 encodes a NAB (NGFI-A-binding protein) transcriptional co-factor. MAB-10 acts with LIN-29 to control the expression of genes required to regulate a subset of differentiation events during the larval-to-adult transition, and we show that the NAB-interaction domain of LIN-29 is conserved in Kruppel-family EGR (early growth response) proteins. In mammals, EGR proteins control the differentiation of multiple cell lineages, and EGR-1 acts with NAB proteins to initiate menarche by regulating the transcription of the luteinizing hormone β subunit. Genome-wide association studies of humans and various studies of mouse recently have implicated the mammalian homologs of the C. elegans heterochronic gene lin-28 in regulating cellular differentiation and the timing of menarche. Our work suggests that human homologs of multiple C. elegans heterochronic genes might act in an evolutionarily conserved pathway to promote cellular differentiation and the onset of puberty. |
| 巻・号 | 138(18) |
| ページ | 4051-62 |
| 公開日 | 2011-9-1 |
| DOI | 10.1242/dev.065417 |
| PII | 138/18/4051 |
| PMID | 21862562 |
| PMC | PMC3160099 |
| MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Caenorhabditis elegans Proteins / physiology* Cell Differentiation / genetics* DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism DNA-Binding Proteins / physiology* Early Growth Response Transcription Factors / genetics Early Growth Response Transcription Factors / metabolism Early Growth Response Transcription Factors / physiology Gene Expression Regulation, Developmental Larva / genetics Larva / growth & development Larva / metabolism Life Cycle Stages / genetics Male Models, Biological Molting / genetics Molting / physiology Repressor Proteins / genetics Repressor Proteins / metabolism Repressor Proteins / physiology Trans-Activators / genetics Trans-Activators / metabolism Trans-Activators / physiology* Transcription Factors / genetics Transcription Factors / metabolism Transcription Factors / physiology* |
| IF | 5.611 |
| 引用数 | 21 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| リソース情報 | |
| 線虫 | tm2497 |