論文 - 詳細
| RRC ID | 46168 |
|---|---|
| 著者 | Mendenhall AR, Wu D, Park SK, Cypser JR, Tedesco PM, Link CD, Phillips PC, Johnson TE. |
| タイトル | Genetic dissection of late-life fertility in Caenorhabditis elegans. |
| ジャーナル | J Gerontol A Biol Sci Med Sci |
| Abstract |
The large post-reproductive life span reported for the free-living hermaphroditic nematode, Caenorhabditis elegans, which lives for about 10 days after its 5-day period of self-reproduction, seems at odds with evolutionary theory. Species with long post-reproductive life spans such as mammals are sometimes explained by a need for parental care or transfer of information. This does not seem a suitable explanation for C elegans. Previous reports have shown that C elegans can regain fertility when mated after the self-fertile period but did not report the functional limits. Here, we report the functional life span of the C elegans germ line when mating with males. We show that C elegans can regain fertility late in life (significantly later than in previous reports) and that the end of this period corresponds quite well to its 3-week total life span. Genetic analysis reveals that late-life fertility is controlled by conserved pathways involved with aging and dietary restriction. |
| 巻・号 | 66(8) |
| ページ | 842-54 |
| 公開日 | 2011-8-1 |
| DOI | 10.1093/gerona/glr089 |
| PII | glr089 |
| PMID | 21622982 |
| PMC | PMC3148761 |
| MeSH | Aging / genetics* Aging / physiology* Aging / psychology* Animals Caenorhabditis elegans / physiology* Diet Fertility / physiology* Germ Cells / physiology Gonads / physiology Longevity* Male Mutation Reproduction / physiology Transcription Factors / metabolism |
| IF | 5.236 |
| 引用数 | 21 |
| WOS 分野 | GERONTOLOGY GERIATRICS & GERONTOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2984 |