RRC ID 46168
Author Mendenhall AR, Wu D, Park SK, Cypser JR, Tedesco PM, Link CD, Phillips PC, Johnson TE.
Title Genetic dissection of late-life fertility in Caenorhabditis elegans.
Journal J Gerontol A Biol Sci Med Sci
Abstract The large post-reproductive life span reported for the free-living hermaphroditic nematode, Caenorhabditis elegans, which lives for about 10 days after its 5-day period of self-reproduction, seems at odds with evolutionary theory. Species with long post-reproductive life spans such as mammals are sometimes explained by a need for parental care or transfer of information. This does not seem a suitable explanation for C elegans. Previous reports have shown that C elegans can regain fertility when mated after the self-fertile period but did not report the functional limits. Here, we report the functional life span of the C elegans germ line when mating with males. We show that C elegans can regain fertility late in life (significantly later than in previous reports) and that the end of this period corresponds quite well to its 3-week total life span. Genetic analysis reveals that late-life fertility is controlled by conserved pathways involved with aging and dietary restriction.
Volume 66(8)
Pages 842-54
Published 2011-8-1
DOI 10.1093/gerona/glr089
PII glr089
PMID 21622982
PMC PMC3148761
MeSH Aging / genetics* Aging / physiology* Aging / psychology* Animals Caenorhabditis elegans / physiology* Diet Fertility / physiology* Germ Cells / physiology Gonads / physiology Longevity* Male Mutation Reproduction / physiology Transcription Factors / metabolism
IF 5.236
Times Cited 21
C.elegans tm2984