| RRC ID |
46168
|
| 著者 |
Mendenhall AR, Wu D, Park SK, Cypser JR, Tedesco PM, Link CD, Phillips PC, Johnson TE.
|
| タイトル |
Genetic dissection of late-life fertility in Caenorhabditis elegans.
|
| ジャーナル |
J Gerontol A Biol Sci Med Sci
|
| Abstract |
The large post-reproductive life span reported for the free-living hermaphroditic nematode, Caenorhabditis elegans, which lives for about 10 days after its 5-day period of self-reproduction, seems at odds with evolutionary theory. Species with long post-reproductive life spans such as mammals are sometimes explained by a need for parental care or transfer of information. This does not seem a suitable explanation for C elegans. Previous reports have shown that C elegans can regain fertility when mated after the self-fertile period but did not report the functional limits. Here, we report the functional life span of the C elegans germ line when mating with males. We show that C elegans can regain fertility late in life (significantly later than in previous reports) and that the end of this period corresponds quite well to its 3-week total life span. Genetic analysis reveals that late-life fertility is controlled by conserved pathways involved with aging and dietary restriction.
|
| 巻・号 |
66(8)
|
| ページ |
842-54
|
| 公開日 |
2011-8-1
|
| DOI |
10.1093/gerona/glr089
|
| PII |
glr089
|
| PMID |
21622982
|
| PMC |
PMC3148761
|
| MeSH |
Aging / genetics*
Aging / physiology*
Aging / psychology*
Animals
Caenorhabditis elegans / physiology*
Diet
Fertility / physiology*
Germ Cells / physiology
Gonads / physiology
Longevity*
Male
Mutation
Reproduction / physiology
Transcription Factors / metabolism
|
| IF |
5.236
|
| 引用数 |
21
|
|
WOS 分野
|
GERONTOLOGY
GERIATRICS & GERONTOLOGY
|
| リソース情報 |
| 線虫 |
tm2984 |
