| RRC ID |
46218
|
| Author |
Tzur YB, Friedland AE, Nadarajan S, Church GM, Calarco JA, Colaiácovo MP.
|
| Title |
Heritable custom genomic modifications in Caenorhabditis elegans via a CRISPR-Cas9 system.
|
| Journal |
Genetics
|
| Abstract |
We adapted the CRISPR-Cas9 system for template-mediated repair of targeted double-strand breaks via homologous recombination in Caenorhabditis elegans, enabling customized and efficient genome editing. This system can be used to create specific insertions, deletions, and base pair changes in the germline of C. elegans.
|
| Volume |
195(3)
|
| Pages |
1181-5
|
| Published |
2013-11-1
|
| DOI |
10.1534/genetics.113.156075
|
| PII |
genetics.113.156075
|
| PMID |
23979579
|
| PMC |
PMC3813848
|
| MeSH |
Animals
CRISPR-Cas Systems*
Caenorhabditis elegans / genetics*
DNA Breaks, Double-Stranded
DNA, Helminth / genetics
Gene Targeting
Genetic Engineering
Genome, Helminth*
Homologous Recombination
Mutagenesis
Mutagenesis, Insertional
RNA Editing / genetics
|
| IF |
4.015
|
| Times Cited |
84
|
|
WOS Category
|
GENETICS & HEREDITY
|
| Resource |
| C.elegans |
tm1791 |
