論文 - 詳細
| RRC ID | 46266 |
|---|---|
| 著者 | Barrios A, Ghosh R, Fang C, Emmons SW, Barr MM. |
| タイトル | PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans. |
| ジャーナル | Nat Neurosci |
| Abstract |
Appetitive behaviors require complex decision making that involves the integration of environmental stimuli and physiological needs. C. elegans mate searching is a male-specific exploratory behavior regulated by two competing needs: food and reproductive appetite. We found that the pigment dispersing factor receptor (PDFR-1) modulates the circuit that encodes the male reproductive drive that promotes male exploration following mate deprivation. PDFR-1 and its ligand, PDF-1, stimulated mate searching in the male, but not in the hermaphrodite. pdf-1 was required in the gender-shared interneuron AIM, and the receptor acted in internal and external environment-sensing neurons of the shared nervous system (URY, PQR and PHA) to produce mate-searching behavior. Thus, the pdf-1 and pdfr-1 pathway functions in non-sex-specific neurons to produce a male-specific, goal-oriented exploratory behavior. Our results indicate that secretin neuropeptidergic signaling is involved in regulating motivational internal states. |
| 巻・号 | 15(12) |
| ページ | 1675-82 |
| 公開日 | 2012-12-1 |
| DOI | 10.1038/nn.3253 |
| PII | nn.3253 |
| PMID | 23143519 |
| PMC | PMC3509246 |
| MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans / metabolism Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism Caenorhabditis elegans Proteins / physiology* Disorders of Sex Development / genetics Disorders of Sex Development / metabolism Disorders of Sex Development / physiopathology Exploratory Behavior / physiology Female Ligands Male Nerve Net / metabolism Nerve Net / physiology* Neuropeptides / metabolism Neuropeptides / physiology* Receptors, G-Protein-Coupled / metabolism Receptors, G-Protein-Coupled / physiology* Sexual Behavior, Animal / physiology* Signal Transduction / physiology* |
| IF | 20.071 |
| 引用数 | 57 |
| WOS 分野 | NEUROSCIENCES |
| リソース情報 | |
| 線虫 | tm4393 tm1996 tm4457 |