論文 - 詳細
| RRC ID | 46274 |
|---|---|
| 著者 | Brown AE, Yemini EI, Grundy LJ, Jucikas T, Schafer WR. |
| タイトル | A dictionary of behavioral motifs reveals clusters of genes affecting Caenorhabditis elegans locomotion. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Visible phenotypes based on locomotion and posture have played a critical role in understanding the molecular basis of behavior and development in Caenorhabditis elegans and other model organisms. However, it is not known whether these human-defined features capture the most important aspects of behavior for phenotypic comparison or whether they are sufficient to discover new behaviors. Here we show that four basic shapes, or eigenworms, previously described for wild-type worms, also capture mutant shapes, and that this representation can be used to build a dictionary of repetitive behavioral motifs in an unbiased way. By measuring the distance between each individual's behavior and the elements in the motif dictionary, we create a fingerprint that can be used to compare mutants to wild type and to each other. This analysis has revealed phenotypes not previously detected by real-time observation and has allowed clustering of mutants into related groups. Behavioral motifs provide a compact and intuitive representation of behavioral phenotypes. |
| 巻・号 | 110(2) |
| ページ | 791-6 |
| 公開日 | 2013-1-8 |
| DOI | 10.1073/pnas.1211447110 |
| PII | 1211447110 |
| PMID | 23267063 |
| PMC | PMC3545781 |
| MeSH | Animals Behavior, Animal / classification Behavior, Animal / physiology* Caenorhabditis elegans / classification Caenorhabditis elegans / genetics* Caenorhabditis elegans / physiology Genes / genetics* Genetics, Behavioral / methods Locomotion / genetics* Locomotion / physiology Models, Biological* Pattern Recognition, Automated / methods Phenotype* Posture / physiology Reproducibility of Results |
| IF | 9.412 |
| 引用数 | 101 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2173 tm3085 tm3092 tm1392 tm2654 tm1325 tm1846 tm2146 |