論文 - 詳細
| RRC ID | 46282 |
|---|---|
| 著者 | Milward K, Busch KE, Murphy RJ, de Bono M, Olofsson B. |
| タイトル | Neuronal and molecular substrates for optimal foraging in Caenorhabditis elegans. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Variation in food quality and abundance requires animals to decide whether to stay on a poor food patch or leave in search of better food. An important question in behavioral ecology asks when is it optimal for an animal to leave a food patch it is depleting. Although optimal foraging is central to evolutionary success, the neural and molecular mechanisms underlying it are poorly understood. Here we investigate the neuronal basis for adaptive food-leaving behavior in response to resource depletion in Caenorhabditis elegans, and identify several of the signaling pathways involved. The ASE neurons, previously implicated in salt chemoattraction, promote food-leaving behavior via a cGMP pathway as food becomes limited. High ambient O(2) promotes food-leaving via the O(2)-sensing neurons AQR, PQR, and URX. Ectopic activation of these neurons using channelrhodopsin is sufficient to induce high food-leaving behavior. In contrast, the neuropeptide receptor NPR-1, which regulates social behavior on food, acts in the ASE neurons, the nociceptive ASH neurons, and in the RMG interneuron to repress food-leaving. Finally, we show that neuroendocrine signaling by TGF-β/DAF-7 and neuronal insulin signaling are necessary for adaptive food-leaving behavior. We suggest that animals integrate information about their nutritional state with ambient oxygen and gustatory stimuli to formulate optimal foraging strategies. |
| 巻・号 | 108(51) |
| ページ | 20672-7 |
| 公開日 | 2011-12-20 |
| DOI | 10.1073/pnas.1106134109 |
| PII | 1106134109 |
| PMID | 22135454 |
| PMC | PMC3251049 |
| MeSH | Animals Behavior, Animal Caenorhabditis elegans / genetics* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Carbon Dioxide / chemistry Chemotaxis Cyclic GMP / metabolism Decision Making Feeding Behavior* Insulin / metabolism Neurons / metabolism Neuropeptides / chemistry Oxygen / chemistry Oxygen / metabolism Rhodopsin / metabolism Signal Transduction Transforming Growth Factor beta / metabolism |
| IF | 9.412 |
| 引用数 | 47 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1782 |