論文 - 詳細
| RRC ID | 46292 |
|---|---|
| 著者 | Cheng C, Shtessel L, Brady MM, Ahmed S. |
| タイトル | Caenorhabditis elegans POT-2 telomere protein represses a mode of alternative lengthening of telomeres with normal telomere lengths. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Canonical telomere repeats at chromosome termini can be maintained by a telomerase-independent pathway termed alternative lengthening of telomeres (ALT). Human cancers that survive via ALT can exhibit long and heterogeneous telomeres, although many telomerase-negative tumors possess telomeres of normal length. Here, we report that Caenorhabditis elegans telomerase mutants that survived via ALT possessed either long or normal telomere lengths. Most ALT strains displayed end-to-end chromosome fusions, suggesting that critical telomere shortening occurred before or concomitant with ALT. ALT required the 9-1-1 DNA damage response complex and its clamp loader, HPR-17. Deficiency for the POT-2 telomere binding protein promoted ALT in telomerase mutants, overcame the requirement for the 9-1-1 complex in ALT, and promoted ALT with normal telomere lengths. We propose that telomerase-deficient human tumors with normal telomere lengths could represent a mode of ALT that is facilitated by telomere capping protein dysfunction. |
| 巻・号 | 109(20) |
| ページ | 7805-10 |
| 公開日 | 2012-5-15 |
| DOI | 10.1073/pnas.1119191109 |
| PII | 1119191109 |
| PMID | 22547822 |
| PMC | PMC3356646 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Indoles Mutation / genetics Polymorphism, Restriction Fragment Length Telomerase / genetics Telomere Homeostasis / physiology* Telomere-Binding Proteins / deficiency Telomere-Binding Proteins / metabolism* |
| IF | 9.412 |
| 引用数 | 13 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 線虫 | tm1579 tm1400 tm1620 |