論文 - 詳細
| RRC ID | 46306 |
|---|---|
| 著者 | Cunningham KA, Hua Z, Srinivasan S, Liu J, Lee BH, Edwards RH, Ashrafi K. |
| タイトル | AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans. |
| ジャーナル | Cell Metab |
| Abstract |
Serotonergic regulation of feeding behavior has been studied intensively, both for an understanding of the basic neurocircuitry of energy balance in various organisms and as a therapeutic target for human obesity. However, its underlying molecular mechanisms remain poorly understood. Here, we show that neural serotonin signaling in C. elegans modulates feeding behavior through inhibition of AMP-activated kinase (AMPK) in interneurons expressing the C. elegans counterpart of human SIM1, a transcription factor associated with obesity. In turn, glutamatergic signaling links these interneurons to pharyngeal neurons implicated in feeding behavior. We show that AMPK-mediated regulation of glutamatergic release is conserved in rat hippocampal neurons. These findings reveal cellular and molecular mediators of serotonergic signaling. |
| 巻・号 | 16(1) |
| ページ | 113-21 |
| 公開日 | 2012-7-3 |
| DOI | 10.1016/j.cmet.2012.05.014 |
| PII | S1550-4131(12)00239-2 |
| PMID | 22768843 |
| PMC | PMC3413480 |
| MeSH | AMP-Activated Protein Kinases Animals Basic Helix-Loop-Helix Transcription Factors / metabolism Caenorhabditis elegans / cytology Caenorhabditis elegans / enzymology* Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cells, Cultured Chemoreceptor Cells / metabolism Cyclic AMP-Dependent Protein Kinases / metabolism Feeding Behavior* Gastrointestinal Motility Glutamic Acid / metabolism* Hippocampus / cytology Pharynx / innervation Pharynx / metabolism Pharynx / physiology Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / metabolism* Rats Receptors, Serotonin / metabolism Serotonergic Neurons / enzymology Serotonergic Neurons / metabolism Serotonin / metabolism Synaptic Transmission* |
| IF | 21.567 |
| 引用数 | 37 |
| WOS 分野 | ENDOCRINOLOGY & METABOLISM CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2877 tm2654 tm1944 tm1325 |