論文 - 詳細
| RRC ID | 46315 |
|---|---|
| 著者 | Pellegrino MW, Farooqui S, Fröhli E, Rehrauer H, Kaeser-Pebernard S, Müller F, Gasser RB, Hajnal A. |
| タイトル | LIN-39 and the EGFR/RAS/MAPK pathway regulate C. elegans vulval morphogenesis via the VAB-23 zinc finger protein. |
| ジャーナル | Development |
| Abstract |
Morphogenesis represents a phase of development during which cell fates are executed. The conserved hox genes are key cell fate determinants during metazoan development, but their role in controlling organ morphogenesis is less understood. Here, we show that the C. elegans hox gene lin-39 regulates epidermal morphogenesis via its novel target, the essential zinc finger protein VAB-23. During the development of the vulva, the egg-laying organ of the hermaphrodite, the EGFR/RAS/MAPK signaling pathway activates, together with LIN-39 HOX, the expression of VAB-23 in the primary cell lineage to control the formation of the seven vulval toroids. VAB-23 regulates the formation of homotypic contacts between contralateral pairs of cells with the same sub-fates at the vulval midline by inducing smp-1 (semaphorin) transcription. In addition, VAB-23 prevents ectopic vulval cell fusions by negatively regulating expression of the fusogen eff-1. Thus, LIN-39 and the EGFR/RAS/MAPK signaling pathway, which specify cell fates earlier during vulval induction, continue to act during the subsequent phase of cell fate execution by regulating various aspects of epidermal morphogenesis. Vulval cell fate specification and execution are, therefore, tightly coupled processes. |
| 巻・号 | 138(21) |
| ページ | 4649-60 |
| 公開日 | 2011-11-1 |
| DOI | 10.1242/dev.071951 |
| PII | 138/21/4649 |
| PMID | 21989912 |
| MeSH | Animals Base Sequence Biomarkers / metabolism Caenorhabditis elegans / anatomy & histology* Caenorhabditis elegans / embryology* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Carrier Proteins / genetics Carrier Proteins / metabolism* Cell Fusion Cell Lineage ErbB Receptors / genetics ErbB Receptors / metabolism* Gene Expression Regulation, Developmental Genes, Reporter Homeodomain Proteins / genetics Homeodomain Proteins / metabolism* Intracellular Signaling Peptides and Proteins Mitogen-Activated Protein Kinases / genetics Mitogen-Activated Protein Kinases / metabolism* Molecular Sequence Data Morphogenesis / physiology* RNA Interference Recombinant Fusion Proteins / genetics Recombinant Fusion Proteins / metabolism Semaphorins / genetics Semaphorins / metabolism Sequence Alignment Signal Transduction / physiology* Transcription Factors / genetics Transcription Factors / metabolism Zinc Fingers |
| IF | 5.611 |
| 引用数 | 16 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| リソース情報 | |
| 線虫 | tm1945 |