論文 - 詳細
| RRC ID | 46324 |
|---|---|
| 著者 | Rosu S, Libuda DE, Villeneuve AM. |
| タイトル | Robust crossover assurance and regulated interhomolog access maintain meiotic crossover number. |
| ジャーナル | Science |
| Abstract |
Most organisms rely on interhomolog crossovers (COs) to ensure proper meiotic chromosome segregation but make few COs per chromosome pair. By monitoring repair events at a defined double-strand break (DSB) site during Caenorhabditis elegans meiosis, we reveal mechanisms that ensure formation of the obligate CO while limiting CO number. We find that CO is the preferred DSB repair outcome in the absence of inhibitory effects of other (nascent) recombination events. Thus, a single DSB per chromosome pair is largely sufficient to ensure CO formation. Further, we show that access to the homolog as a repair template is regulated, shutting down simultaneously for both CO and noncrossover (NCO) pathways. We propose that regulation of interhomolog access limits CO number and contributes to CO interference. |
| 巻・号 | 334(6060) |
| ページ | 1286-9 |
| 公開日 | 2011-12-2 |
| DOI | 10.1126/science.1212424 |
| PII | 334/6060/1286 |
| PMID | 22144627 |
| PMC | PMC3360972 |
| MeSH | Animals Caenorhabditis elegans / genetics* Chromosome Pairing Crossing Over, Genetic* DNA Breaks, Double-Stranded DNA Repair DNA, Helminth / genetics* Meiosis* Recombination, Genetic |
| IF | 41.846 |
| 引用数 | 73 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1866 |