論文 - 詳細
| RRC ID | 46472 |
|---|---|
| 著者 | Xie L, Gao S, Alcaire SM, Aoyagi K, Wang Y, Griffin JK, Stagljar I, Nagamatsu S, Zhen M. |
| タイトル | NLF-1 delivers a sodium leak channel to regulate neuronal excitability and modulate rhythmic locomotion. |
| ジャーナル | Neuron |
| Abstract |
A cation channel NCA/UNC-79/UNC-80 affects neuronal activity. We report here the identification of a conserved endoplasmic reticulum protein NLF-1 (NCA localization factor-1) that regulates neuronal excitability and locomotion through the NCA channel. In C. elegans, the loss of either NLF-1 or NCA leads to a reduced sodium leak current, and a hyperpolarized resting membrane potential in premotor interneurons. This results in a decreased premotor interneuron activity that reduces the initiation and sustainability of rhythmic locomotion. NLF-1 promotes axonal localization of all NCA reporters. Its mouse homolog mNLF-1 functionally substitutes for NLF-1 in C. elegans, interacts with the mammalian sodium leak channel NALCN in vitro, and potentiates sodium leak currents in primary cortical neuron cultures. Taken together, an ER protein NLF-1 delivers a sodium leak channel to maintain neuronal excitability and potentiates a premotor interneuron network critical for C. elegans rhythmic locomotion. |
| 巻・号 | 77(6) |
| ページ | 1069-82 |
| 公開日 | 2013-3-20 |
| DOI | 10.1016/j.neuron.2013.01.018 |
| PII | S0896-6273(13)00084-6 |
| PMID | 23522043 |
| MeSH | Animals Axons / metabolism Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Caenorhabditis elegans Proteins / physiology Cells, Cultured Endoplasmic Reticulum / metabolism Gene Knockdown Techniques / methods Ion Channels Locomotion / physiology* Membrane Proteins Mice Mice, Inbred C57BL Molecular Sequence Data Neurons / metabolism* Nuclear Proteins Periodicity* Sodium Channels / genetics Sodium Channels / metabolism* Sodium Channels / physiology Transcription Factors / genetics Transcription Factors / metabolism* Transcription Factors / physiology |
| IF | 14.415 |
| 引用数 | 35 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3631 |