論文 - 詳細
| RRC ID | 46512 |
|---|---|
| 著者 | Sugioka K, Mizumoto K, Sawa H. |
| タイトル | Wnt regulates spindle asymmetry to generate asymmetric nuclear β-catenin in C. elegans. |
| ジャーナル | Cell |
| Abstract |
Extrinsic signals received by a cell can induce remodeling of the cytoskeleton, but the downstream effects of cytoskeletal changes on gene expression have not been well studied. Here, we show that during telophase of an asymmetric division in C. elegans, extrinsic Wnt signaling modulates spindle structures through APR-1/APC, which in turn promotes asymmetrical nuclear localization of WRM-1/β-catenin and POP-1/TCF. APR-1 that localized asymmetrically along the cortex established asymmetric distribution of astral microtubules, with more microtubules found on the anterior side. Perturbation of the Wnt signaling pathway altered this microtubule asymmetry and led to changes in nuclear WRM-1 asymmetry, gene expression, and cell-fate determination. Direct manipulation of spindle asymmetry by laser irradiation altered the asymmetric distribution of nuclear WRM-1. Moreover, laser manipulation of the spindles rescued defects in nuclear POP-1 asymmetry in wnt mutants. Our results reveal a mechanism in which the nuclear localization of proteins is regulated through the modulation of microtubules. |
| 巻・号 | 146(6) |
| ページ | 942-54 |
| 公開日 | 2011-9-16 |
| DOI | 10.1016/j.cell.2011.07.043 |
| PII | S0092-8674(11)00887-7 |
| PMID | 21925317 |
| MeSH | Animals Caenorhabditis elegans / cytology* Caenorhabditis elegans / embryology Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism* Cell Nucleus / metabolism Cytoskeletal Proteins / metabolism* Kinesins / metabolism Microtubules / metabolism Signal Transduction* Spindle Apparatus Wnt Proteins / metabolism* beta Catenin / metabolism |
| IF | 38.637 |
| 引用数 | 50 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2114 tm785 tm2143 tm375 |