RRC ID 46539
著者 Yang CC, Chen D, Lee SS, Walter L.
タイトル The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity.
ジャーナル Aging Cell
Abstract Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that mitochondrial morphology and IIS cooperate to modulate aging.
巻・号 10(4)
ページ 724-8
公開日 2011-8-1
DOI 10.1111/j.1474-9726.2011.00711.x
PMID 21463460
PMC PMC3135752
MeSH Animals Animals, Genetically Modified Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Dynamins / genetics Dynamins / metabolism* Insulin / metabolism* Longevity / physiology Phenotype Signal Transduction
IF 7.238
引用数 35
WOS 分野 GERIATRICS & GERONTOLOGY CELL BIOLOGY
リソース情報
線虫 tm1108