RRC ID 46539
Author Yang CC, Chen D, Lee SS, Walter L.
Title The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity.
Journal Aging Cell
Abstract Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that mitochondrial morphology and IIS cooperate to modulate aging.
Volume 10(4)
Pages 724-8
Published 2011-8-1
DOI 10.1111/j.1474-9726.2011.00711.x
PMID 21463460
PMC PMC3135752
MeSH Animals Animals, Genetically Modified Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Dynamins / genetics Dynamins / metabolism* Insulin / metabolism* Longevity / physiology Phenotype Signal Transduction
IF 7.238
Times Cited 35
C.elegans tm1108