Reference - Detail
| RRC ID | 46539 |
|---|---|
| Author | Yang CC, Chen D, Lee SS, Walter L. |
| Title | The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity. |
| Journal | Aging Cell |
| Abstract |
Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that mitochondrial morphology and IIS cooperate to modulate aging. |
| Volume | 10(4) |
| Pages | 724-8 |
| Published | 2011-8-1 |
| DOI | 10.1111/j.1474-9726.2011.00711.x |
| PMID | 21463460 |
| PMC | PMC3135752 |
| MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Dynamins / genetics Dynamins / metabolism* Insulin / metabolism* Longevity / physiology Phenotype Signal Transduction |
| IF | 7.238 |
| Times Cited | 35 |
| WOS Category | GERIATRICS & GERONTOLOGY CELL BIOLOGY |
| Resource | |
| C.elegans | tm1108 |