論文 - 詳細
| RRC ID | 46539 |
|---|---|
| 著者 | Yang CC, Chen D, Lee SS, Walter L. |
| タイトル | The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity. |
| ジャーナル | Aging Cell |
| Abstract |
Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that mitochondrial morphology and IIS cooperate to modulate aging. |
| 巻・号 | 10(4) |
| ページ | 724-8 |
| 公開日 | 2011-8-1 |
| DOI | 10.1111/j.1474-9726.2011.00711.x |
| PMID | 21463460 |
| PMC | PMC3135752 |
| MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Dynamins / genetics Dynamins / metabolism* Insulin / metabolism* Longevity / physiology Phenotype Signal Transduction |
| IF | 7.238 |
| 引用数 | 35 |
| WOS 分野 | GERIATRICS & GERONTOLOGY CELL BIOLOGY |
| リソース情報 | |
| 線虫 | tm1108 |