論文 - 詳細
| RRC ID | 46551 |
|---|---|
| 著者 | Zhang X, Zabinsky R, Teng Y, Cui M, Han M. |
| タイトル | microRNAs play critical roles in the survival and recovery of Caenorhabditis elegans from starvation-induced L1 diapause. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Environmental stresses and nutrition availability critically affect animal development. Numerous animal species across multiple phyla enter developmental arrest for long-term survival in unfavorable environments and resume development upon stress removal. Here we show that compromising overall microRNA (miRNA) functions or mutating certain individual miRNAs impairs the long-term survival of nematodes during starvation-induced L1 diapause. We provide evidence that miRNA miR-71 is not required for the animals' entry into L1 diapause, but plays a critical role in long-term survival by repressing the expression of insulin receptor/PI3K pathway genes and genes acting downstream or in parallel to the pathway. Furthermore, miR-71 plays a prominent role in developmental recovery from L1 diapause partly through repressing the expression of certain heterochronic genes. The presented results indicate that interactions between multiple miRNAs and likely a large number of their mRNA targets in multiple pathways regulate the response to starvation-induced L1 diapause. |
| 巻・号 | 108(44) |
| ページ | 17997-8002 |
| 公開日 | 2011-11-1 |
| DOI | 10.1073/pnas.1105982108 |
| PII | 1105982108 |
| PMID | 22011579 |
| PMC | PMC3207661 |
| MeSH | 3' Untranslated Regions Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Cell Division MicroRNAs / physiology* Mutation Starvation* |
| IF | 9.412 |
| 引用数 | 54 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
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オルトメトリクス指標項目
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| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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| 線虫 | tm3681 tm2432 |