RRC ID 46551
著者 Zhang X, Zabinsky R, Teng Y, Cui M, Han M.
タイトル microRNAs play critical roles in the survival and recovery of Caenorhabditis elegans from starvation-induced L1 diapause.
ジャーナル Proc Natl Acad Sci U S A
Abstract Environmental stresses and nutrition availability critically affect animal development. Numerous animal species across multiple phyla enter developmental arrest for long-term survival in unfavorable environments and resume development upon stress removal. Here we show that compromising overall microRNA (miRNA) functions or mutating certain individual miRNAs impairs the long-term survival of nematodes during starvation-induced L1 diapause. We provide evidence that miRNA miR-71 is not required for the animals' entry into L1 diapause, but plays a critical role in long-term survival by repressing the expression of insulin receptor/PI3K pathway genes and genes acting downstream or in parallel to the pathway. Furthermore, miR-71 plays a prominent role in developmental recovery from L1 diapause partly through repressing the expression of certain heterochronic genes. The presented results indicate that interactions between multiple miRNAs and likely a large number of their mRNA targets in multiple pathways regulate the response to starvation-induced L1 diapause.
巻・号 108(44)
ページ 17997-8002
公開日 2011-11-1
DOI 10.1073/pnas.1105982108
PII 1105982108
PMID 22011579
PMC PMC3207661
MeSH 3' Untranslated Regions Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Cell Division MicroRNAs / physiology* Mutation Starvation*
IF 9.412
引用数 54
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
線虫 tm3681 tm2432