論文 - 詳細
RRC ID | 46578 |
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著者 | Choi MS, Yoo AS, Greenwald I. |
タイトル | sel-11 and cdc-42, two negative modulators of LIN-12/Notch activity in C. elegans. |
ジャーナル | PLoS One |
Abstract |
BACKGROUND:LIN-12/Notch signaling is important for cell-cell interactions during development, and mutations resulting in constitutive LIN-12/Notch signaling can cause cancer. Loss of negative regulators of lin-12/Notch activity has the potential for influencing cell fate decisions during development and the genesis or aggressiveness of cancer. METHODOLOGY/PRINCIPAL FINDINGS:We describe two negative modulators of lin-12 activity in C. elegans. One gene, sel-11, was initially defined as a suppressor of a lin-12 hypomorphic allele; the other gene, cdc-42, is a well-studied Rho GTPase. Here, we show that SEL-11 corresponds to yeast Hrd1p and mammalian Synoviolin. We also show that cdc-42 has the genetic properties consistent with negative regulation of lin-12 activity during vulval precursor cell fate specification. CONCLUSIONS/SIGNIFICANCE:Our results underscore the multiplicity of negative regulatory mechanisms that impact on lin-12/Notch activity and suggest novel mechanisms by which constitutive lin-12/Notch activity might be exacerbated in cancer. |
巻・号 | 5(7) |
ページ | e11885 |
公開日 | 2010-7-29 |
DOI | 10.1371/journal.pone.0011885 |
PMID | 20686701 |
PMC | PMC2912376 |
MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Membrane Proteins / genetics Membrane Proteins / metabolism* Polymerase Chain Reaction RNA Interference Receptors, Notch |
IF | 2.74 |
引用数 | 7 |
WOS 分野 | CELL BIOLOGY |
リソース情報 | |
線虫 | tm1743 |