論文 - 詳細
| RRC ID | 46580 |
|---|---|
| 著者 | Cornejo Castro EM, Waak J, Weber SS, Fiesel FC, Oberhettinger P, Schütz M, Autenrieth IB, Springer W, Kahle PJ. |
| タイトル | Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans. |
| ジャーナル | J Neural Transm (Vienna) |
| Abstract |
DJ-1 is a neuroprotective gene mutated in recessive Parkinson's disease (PD). In addition to direct protective functions in neurons, DJ-1 regulates neuroinflammatory signaling in primary mouse brain astrocytes. To assess the influence of DJ-1 on innate immunity signaling in vivo, we have generated djr-1 knockout Caenorhabditis elegans. When grown on pathogenic gram-negative bacteria, djr-1 (-/-) worms showed stronger phosphorylation of p38 mitogen-activated protein kinase (PMK-1) and hyper-induction of PMK-1 target genes. Thus, PD-associated DJ-1 contributes to regulation of innate immunity. |
| 巻・号 | 117(5) |
| ページ | 599-604 |
| 公開日 | 2010-5-1 |
| DOI | 10.1007/s00702-010-0397-4 |
| PMID | 20376509 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / immunology* Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Gene Expression Regulation / physiology Gene Knockout Techniques Immunity, Innate / genetics* Mitogen-Activated Protein Kinases / metabolism Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism Parkinson Disease / genetics Parkinson Disease / immunology Parkinson Disease / metabolism Phosphorylation / physiology Signal Transduction / immunology* Zebrafish Proteins / genetics Zebrafish Proteins / metabolism |
| IF | 3.505 |
| 引用数 | 20 |
| リソース情報 | |
| 線虫 | tm918 tm1346 |