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  • 検索条件 : 絞込み (MeSH = Parkinson Disease / genetics)
生物種 リソース名 タイトル
ヒト・動物細胞 Atg5^(+/+)MEF(RCB2710) , Atg5^(-/-)MEF(RCB2711) Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control.
線虫 tm4481 ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.
ヒト・動物細胞 201B7(HPS0063) , 409B2(HPS0076) Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplication.
線虫 pink-1(tm1779), lrk-1(tm1898) Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration in C. elegans Models of Parkinson's Disease.
ヒト・動物細胞 201B7(HPS0063) Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson's disease.
ショウジョウバエ DGRC#140691 PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions.
ショウジョウバエ DGRC#112001 Death by over-eating: The Gaucher disease associated gene GBA1, identified in a screen for mediators of autophagic cell death, is necessary for developmental cell death in Drosophila midgut.
ショウジョウバエ Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila.
ショウジョウバエ ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson's Disease.
遺伝子材料 phRIT2 (RDB16941) , CSII-CMV-MCS-IRES2-Venus (RDB04383) , pCAG-HIVgp (RDB04394) , pCMV-VSV-G-RSV-Rev (RDB04393) In silico drug screening by using genome-wide association study data repurposed dabrafenib, an anti-melanoma drug, for Parkinson's disease.
線虫 tm1779 , tm1898 , tm598 Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration in C. elegans Models of Parkinson's Disease.
ヒト・動物細胞 , ショウジョウバエ HeLa , 293T(RCB2202) Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c.
線虫 tm1779 Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases.
線虫 tm1898 , tm1779 C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease.
線虫 tm918 , tm1346 Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans.
線虫 tm918 , tm1346 Age- and manganese-dependent modulation of dopaminergic phenotypes in a C. elegans DJ-1 genetic model of Parkinson's disease.
ヒト・動物細胞 COS-7(RCB0539) Polyglutamine expansion mutation yields a pathological epitope linked to nucleation of protein aggregate: determinant of Huntington's disease onset.
ヒト・動物細胞 JFP-J1(RCB2309) Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults.
ゼブラフィッシュ Tg(HuC:Kaede)/rw0130a Quantitative proteomics reveals diverse roles of miR-148a from gastric cancer progression to neurological development.
線虫 tm1898 Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity.