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Human and Animal Cells Atg5^(+/+)MEF(RCB2710) , Atg5^(-/-)MEF(RCB2711) Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control.
C.elegans tm4481 ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.
Human and Animal Cells 201B7(HPS0063) , 409B2(HPS0076) Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplication.
C.elegans pink-1(tm1779), lrk-1(tm1898) Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration in C. elegans Models of Parkinson's Disease.
Human and Animal Cells 201B7(HPS0063) Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson's disease.
Drosophila DGRC#140691 PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions.
Drosophila DGRC#112001 Death by over-eating: The Gaucher disease associated gene GBA1, identified in a screen for mediators of autophagic cell death, is necessary for developmental cell death in Drosophila midgut.
Drosophila Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila.
Drosophila ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson's Disease.
DNA material phRIT2 (RDB16941) , CSII-CMV-MCS-IRES2-Venus (RDB04383) , pCAG-HIVgp (RDB04394) , pCMV-VSV-G-RSV-Rev (RDB04393) In silico drug screening by using genome-wide association study data repurposed dabrafenib, an anti-melanoma drug, for Parkinson's disease.
C.elegans tm1779 , tm1898 , tm598 Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration in C. elegans Models of Parkinson's Disease.
Human and Animal Cells , Drosophila HeLa , 293T(RCB2202) Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c.
C.elegans tm1779 Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases.
C.elegans tm1898 , tm1779 C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease.
C.elegans tm918 , tm1346 Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans.
C.elegans tm918 , tm1346 Age- and manganese-dependent modulation of dopaminergic phenotypes in a C. elegans DJ-1 genetic model of Parkinson's disease.
Human and Animal Cells COS-7(RCB0539) Polyglutamine expansion mutation yields a pathological epitope linked to nucleation of protein aggregate: determinant of Huntington's disease onset.
Human and Animal Cells JFP-J1(RCB2309) Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults.
Zebrafish Tg(HuC:Kaede)/rw0130a Quantitative proteomics reveals diverse roles of miR-148a from gastric cancer progression to neurological development.
C.elegans tm1898 Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity.