論文 - 詳細
| RRC ID | 46587 |
|---|---|
| 著者 | Edmonds JW, Prasain JK, Dorand D, Yang Y, Hoang HD, Vibbert J, Kubagawa HM, Miller MA. |
| タイトル | Insulin/FOXO signaling regulates ovarian prostaglandins critical for reproduction. |
| ジャーナル | Dev Cell |
| Abstract |
Abnormalities in insulin/IGF-1 signaling are associated with infertility, but the molecular mechanisms are not well understood. Here we use liquid chromatography with electrospray ionization tandem mass spectrometry to show that the C. elegans insulin/FOXO pathway regulates the metabolism of locally acting lipid hormones called prostaglandins. C. elegans prostaglandins are synthesized without prostaglandin G/H synthase homologs, the targets of nonsteroidal anti-inflammatory drugs. Our results support the model that insulin signaling promotes the conversion of oocyte polyunsaturated fatty acids (PUFAs) into F-series prostaglandins that guide sperm to the fertilization site. Reduction in insulin signaling activates DAF-16/FOXO, which represses the transcription of germline and intestinal genes required to deliver PUFAs to oocytes in lipoprotein complexes. Nutritional and neuroendocrine cues target this mechanism to control prostaglandin metabolism and reproductive output. Prostaglandins may be conserved sperm guidance factors and widespread downstream effectors of insulin actions that influence both reproductive and nonreproductive processes. |
| 巻・号 | 19(6) |
| ページ | 858-71 |
| 公開日 | 2010-12-14 |
| DOI | 10.1016/j.devcel.2010.11.005 |
| PII | S1534-5807(10)00532-0 |
| PMID | 21145501 |
| PMC | PMC3026445 |
| MeSH | Animals Animals, Genetically Modified Base Sequence Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* DNA Primers / genetics Fatty Acids, Unsaturated / metabolism Female Forkhead Transcription Factors / physiology* Genes, Helminth Insulin / physiology* Male Models, Biological Mutation Oocytes / physiology Ovary / physiology* Prostaglandins F / physiology* Receptor, Insulin / genetics Receptor, Insulin / physiology Reproduction / physiology Signal Transduction Spectrometry, Mass, Electrospray Ionization Sperm Motility / physiology Tandem Mass Spectrometry Transcription Factors / physiology |
| IF | 10.092 |
| 引用数 | 45 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3294 |