論文 - 詳細
| RRC ID | 46592 |
|---|---|
| 著者 | Galvin BD, Denning DP, Horvitz HR. |
| タイトル | SPK-1, an SR protein kinase, inhibits programmed cell death in Caenorhabditis elegans. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
To identify genes involved in protecting cells from programmed cell death in Caenorhabditis elegans, we performed a genetic screen to isolate mutations that cause an increase in the number of programmed cell deaths. We screened for suppressors of the cell-death defect caused by a partial loss-of-function mutation in ced-4, which encodes an Apaf-1 homolog that promotes programmed cell death by activating the caspase CED-3. We identified one extragenic ced-4 suppressor, which has a mutation in the gene spk-1. The spk-1 gene encodes a protein homologous to serine-arginine-rich (SR) protein kinases, which are thought to regulate splicing. Previous work suggests that ced-4 can be alternatively spliced and that the splice variants function oppositely, with the longer transcript (ced-4L) inhibiting programmed cell death. spk-1 might promote cell survival by increasing the amount of the protective ced-4L splice variant. We conclude that programmed cell death in C. elegans is regulated by an alternative splicing event controlled by the SR protein kinase SPK-1. |
| 巻・号 | 108(5) |
| ページ | 1998-2003 |
| 公開日 | 2011-2-1 |
| DOI | 10.1073/pnas.1018805108 |
| PII | 1018805108 |
| PMID | 21245325 |
| PMC | PMC3033281 |
| MeSH | Alleles Alternative Splicing Animals Apoptosis* Caenorhabditis elegans / cytology Caenorhabditis elegans / enzymology* Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Calcium-Binding Proteins / genetics Genes, Helminth Models, Genetic Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / metabolism* Suppression, Genetic |
| IF | 9.412 |
| 引用数 | 8 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm837 tm722 |