Reference - Detail
| RRC ID | 46633 |
|---|---|
| Author | Lesch BJ, Bargmann CI. |
| Title | The homeodomain protein hmbx-1 maintains asymmetric gene expression in adult C. elegans olfactory neurons. |
| Journal | Genes Dev |
| Abstract |
Differentiated neurons balance the need to maintain a stable identity with their flexible responses to dynamic environmental inputs. Here we characterize these opposing influences on gene expression in Caenorhabditis elegans olfactory neurons. Using transcriptional reporters that are expressed differentially in two olfactory neurons, AWC(ON) and AWC(OFF), we identify mutations that affect the long-term maintenance of appropriate chemoreceptor expression. A newly identified gene from this screen, the conserved transcription factor hmbx-1, stabilizes AWC gene expression in adult animals through dosage-sensitive interactions with its transcriptional targets. The late action of hmbx-1 complements the early role of the transcriptional repressor gene nsy-7: Both repress expression of multiple AWC(OFF) genes in AWC(ON) neurons, but they act at different developmental stages. Environmental signals are superimposed onto this stable cell identity through at least two different transcriptional pathways that regulate individual chemoreceptor genes: a cGMP pathway regulated by sensory activity, and a daf-7 (TGF-beta)/daf-3 (SMAD repressor) pathway regulated by specific components of the density-dependent C. elegans dauer pheromone. |
| Volume | 24(16) |
| Pages | 1802-15 |
| Published | 2010-8-15 |
| DOI | 10.1101/gad.1932610 |
| PII | 24/16/1802 |
| PMID | 20713521 |
| PMC | PMC2922507 |
| MeSH | Alleles Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism* Gene Expression Regulation* Green Fluorescent Proteins / genetics Homeodomain Proteins / genetics* Homeodomain Proteins / metabolism* Mutation / genetics Olfactory Nerve / metabolism* Signal Transduction Suppression, Genetic / genetics Transcription Factors / genetics* Transcription Factors / metabolism* Transforming Growth Factor beta / metabolism Transgenes / genetics |
| IF | 9.527 |
| Times Cited | 21 |
| WOS Category | GENETICS & HEREDITY DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | F1000Research |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm1274 |