Reference - Detail
| RRC ID | 46648 |
|---|---|
| Author | Marsh EK, van den Berg MC, May RC. |
| Title | A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans. |
| Journal | PLoS One |
| Abstract |
Lysozymes are antimicrobial enzymes that perform a critical role in resisting infection in a wide-range of eukaryotes. However, using the nematode Caenorhabditis elegans as a model host we now demonstrate that deletion of the protist type lysozyme LYS-7 renders animals susceptible to killing by the fatal fungal human pathogen Cryptococcus neoformans, but, remarkably, enhances tolerance to the enteric bacteria Salmonella Typhimurium. This trade-off in immunological susceptibility in C. elegans is further mediated by the reciprocal activity of lys-7 and the tyrosine kinase abl-1. Together this implies a greater complexity in C. elegans innate immune function than previously thought. |
| Volume | 6(3) |
| Pages | e16839 |
| Published | 2011-3-2 |
| DOI | 10.1371/journal.pone.0016839 |
| PMID | 21399680 |
| PMC | PMC3047536 |
| MeSH | Adaptation, Physiological / genetics* Animals Caenorhabditis elegans / enzymology Caenorhabditis elegans / genetics* Caenorhabditis elegans / microbiology* Caenorhabditis elegans Proteins / genetics* Cryptococcosis / genetics Cryptococcosis / microbiology Cryptococcus neoformans / physiology Dosage Compensation, Genetic Genes, Helminth / genetics* Humans Muramidase / genetics* Mutation / genetics Phenotype Proto-Oncogene Proteins c-abl / genetics* Salmonella Infections, Animal / genetics Salmonella Infections, Animal / microbiology Salmonella typhimurium / physiology* Suppression, Genetic |
| IF | 2.74 |
| Times Cited | 15 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Blogs |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm420 tm2319 |