| RRC ID |
46648
|
| Author |
Marsh EK, van den Berg MC, May RC.
|
| Title |
A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans.
|
| Journal |
PLoS One
|
| Abstract |
Lysozymes are antimicrobial enzymes that perform a critical role in resisting infection in a wide-range of eukaryotes. However, using the nematode Caenorhabditis elegans as a model host we now demonstrate that deletion of the protist type lysozyme LYS-7 renders animals susceptible to killing by the fatal fungal human pathogen Cryptococcus neoformans, but, remarkably, enhances tolerance to the enteric bacteria Salmonella Typhimurium. This trade-off in immunological susceptibility in C. elegans is further mediated by the reciprocal activity of lys-7 and the tyrosine kinase abl-1. Together this implies a greater complexity in C. elegans innate immune function than previously thought.
|
| Volume |
6(3)
|
| Pages |
e16839
|
| Published |
2011-3-2
|
| DOI |
10.1371/journal.pone.0016839
|
| PMID |
21399680
|
| PMC |
PMC3047536
|
| MeSH |
Adaptation, Physiological / genetics*
Animals
Caenorhabditis elegans / enzymology
Caenorhabditis elegans / genetics*
Caenorhabditis elegans / microbiology*
Caenorhabditis elegans Proteins / genetics*
Cryptococcosis / genetics
Cryptococcosis / microbiology
Cryptococcus neoformans / physiology
Dosage Compensation, Genetic
Genes, Helminth / genetics*
Humans
Muramidase / genetics*
Mutation / genetics
Phenotype
Proto-Oncogene Proteins c-abl / genetics*
Salmonella Infections, Animal / genetics
Salmonella Infections, Animal / microbiology
Salmonella typhimurium / physiology*
Suppression, Genetic
|
| IF |
2.74
|
| Times Cited |
15
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| C.elegans |
tm420
tm2319 |
