論文 - 詳細
| RRC ID | 46693 |
|---|---|
| 著者 | Yamada K, Hirotsu T, Matsuki M, Butcher RA, Tomioka M, Ishihara T, Clardy J, Kunitomo H, Iino Y. |
| タイトル | Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans. |
| ジャーナル | Science |
| Abstract |
Population density-dependent dispersal is a well-characterized strategy of animal behavior in which dispersal rate increases when population density is higher. Caenorhabditis elegans shows positive chemotaxis to a set of odorants, but the chemotaxis switches from attraction to dispersal after prolonged exposure to the odorants. We show here that this plasticity of olfactory behavior is dependent on population density and that this regulation is mediated by pheromonal signaling. We show that a peptide, suppressor of NEP-2 (SNET-1), negatively regulates olfactory plasticity and that its expression is down-regulated by the pheromone. NEP-2, a homolog of the extracellular peptidase neprilysin, antagonizes SNET-1, and this function is essential for olfactory plasticity. These results suggest that population density information is transmitted through the external pheromone and endogenous peptide signaling to modulate chemotactic behavior. |
| 巻・号 | 329(5999) |
| ページ | 1647-50 |
| 公開日 | 2010-9-24 |
| DOI | 10.1126/science.1192020 |
| PII | 329/5999/1647 |
| PMID | 20929849 |
| PMC | PMC3021133 |
| MeSH | Adaptation, Physiological* Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Chemotaxis* Down-Regulation Gene Expression Regulation Mutation Neprilysin / genetics Neprilysin / metabolism* Neurites / metabolism Neurons / metabolism Odorants Olfactory Pathways / cytology Olfactory Pathways / physiology Pheromones / metabolism* Population Density Recombinant Fusion Proteins / metabolism Repressor Proteins / genetics Repressor Proteins / metabolism* Signal Transduction* Smell / physiology |
| IF | 41.846 |
| 引用数 | 53 |
| WOS 分野 | MULTIDISCIPLINARY SCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1946 tm2943 |