論文 - 詳細
| RRC ID | 46702 |
|---|---|
| 著者 | Zhang H, Landmann F, Zahreddine H, Rodriguez D, Koch M, Labouesse M. |
| タイトル | A tension-induced mechanotransduction pathway promotes epithelial morphogenesis. |
| ジャーナル | Nature |
| Abstract |
Mechanotransduction refers to the transformation of physical forces into chemical signals. It generally involves stretch-sensitive channels or conformational change of cytoskeleton-associated proteins. Mechanotransduction is crucial for the physiology of several organs and for cell migration. The extent to which mechanical inputs contribute to development, and how they do this, remains poorly defined. Here we show that a mechanotransduction pathway operates between the body-wall muscles of Caenorhabditis elegans and the epidermis. This pathway involves, in addition to a Rac GTPase, three signalling proteins found at the hemidesmosome: p21-activated kinase (PAK-1), the adaptor GIT-1 and its partner PIX-1. The phosphorylation of intermediate filaments is one output of this pathway. Tension exerted by adjacent muscles or externally exerted mechanical pressure maintains GIT-1 at hemidesmosomes and stimulates PAK-1 activity through PIX-1 and Rac. This pathway promotes the maturation of a hemidesmosome into a junction that can resist mechanical stress and contributes to coordinating the morphogenesis of epidermal and muscle tissues. Our findings suggest that the C. elegans hemidesmosome is not only an attachment structure, but also a mechanosensor that responds to tension by triggering signalling processes. We suggest that similar pathways could promote epithelial morphogenesis or wound healing in other organisms in which epithelial cells adhere to tension-generating contractile cells. |
| 巻・号 | 471(7336) |
| ページ | 99-103 |
| 公開日 | 2011-3-3 |
| DOI | 10.1038/nature09765 |
| PII | nature09765 |
| PMID | 21368832 |
| MeSH | Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / embryology* Caenorhabditis elegans / enzymology Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism Carrier Proteins / metabolism Epidermal Cells Epidermis / embryology* Hemidesmosomes / metabolism Intermediate Filaments / metabolism Mechanotransduction, Cellular / physiology* Morphogenesis* Muscle Contraction / physiology* Muscles / embryology Muscles / physiology Phenotype Phosphorylation Signal Transduction p21-Activated Kinases / metabolism |
| IF | 42.779 |
| 引用数 | 145 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 44 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| 線虫 | tm403 tm1962 |