RRC ID 46748
Author Teramoto T, Sternick LA, Kage-Nakadai E, Sajjadi S, Siembida J, Mitani S, Iwasaki K, Lambie EJ.
Title Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel.
Journal PLoS One
Abstract Systemic magnesium homeostasis in mammals is primarily governed by the activities of the TRPM6 and TRPM7 cation channels, which mediate both uptake by the intestinal epithelial cells and reabsorption by the distal convoluted tubule cells in the kidney. In the nematode, C. elegans, intestinal magnesium uptake is dependent on the activities of the TRPM channel proteins, GON-2 and GTL-1. In this paper we provide evidence that another member of the TRPM protein family, GTL-2, acts within the C. elegans excretory cell to mediate the excretion of excess magnesium. Thus, the activity of GTL-2 balances the activities of the paralogous TRPM channel proteins, GON-2 and GTL-1.
Volume 5(3)
Pages e9589
Published 2010-3-8
DOI 10.1371/journal.pone.0009589
PMID 20221407
PMC PMC2833210
MeSH Animals Animals, Genetically Modified Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism* Cells, Cultured Electrophysiology / methods Genetic Vectors Ion Channels / metabolism* Kidney / metabolism Magnesium / metabolism* Models, Biological Mutation Potassium / chemistry RNA Interference TRPM Cation Channels / metabolism* Trace Elements
IF 2.74
Times Cited 20
C.elegans tm1463