論文 - 詳細
| RRC ID | 46748 |
|---|---|
| 著者 | Teramoto T, Sternick LA, Kage-Nakadai E, Sajjadi S, Siembida J, Mitani S, Iwasaki K, Lambie EJ. |
| タイトル | Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel. |
| ジャーナル | PLoS One |
| Abstract |
Systemic magnesium homeostasis in mammals is primarily governed by the activities of the TRPM6 and TRPM7 cation channels, which mediate both uptake by the intestinal epithelial cells and reabsorption by the distal convoluted tubule cells in the kidney. In the nematode, C. elegans, intestinal magnesium uptake is dependent on the activities of the TRPM channel proteins, GON-2 and GTL-1. In this paper we provide evidence that another member of the TRPM protein family, GTL-2, acts within the C. elegans excretory cell to mediate the excretion of excess magnesium. Thus, the activity of GTL-2 balances the activities of the paralogous TRPM channel proteins, GON-2 and GTL-1. |
| 巻・号 | 5(3) |
| ページ | e9589 |
| 公開日 | 2010-3-8 |
| DOI | 10.1371/journal.pone.0009589 |
| PMID | 20221407 |
| PMC | PMC2833210 |
| MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism* Cells, Cultured Electrophysiology / methods Genetic Vectors Ion Channels / metabolism* Kidney / metabolism Magnesium / metabolism* Models, Biological Mutation Potassium / chemistry RNA Interference TRPM Cation Channels / metabolism* Trace Elements |
| IF | 2.74 |
| 引用数 | 20 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 線虫 | tm1463 |