RRC ID 47001
Author Araki A, Kubota T, Aoyama K, Mikami Y, Fromont J, Kobayashi J.
Title Nagelamides Q and R, novel dimeric bromopyrrole alkaloids from sponges Agelas sp.
Journal Org Lett
Abstract Two new dimeric bromopyrrole alkaloids, nagelamides Q (1) and R (2), have been isolated from Okinawan marine sponges of the genus Agelas (SS-1134 and SS-956, respectively), and the structures and stereochemistry were elucidated from spectroscopic data. Nagelamide Q (1) is a rare dimeric bromopyrrole alkaloid possessing a pyrrolidine ring, while nagelamide R (2) is the first bromopyrrole alkaloid having an oxazoline ring. Nagelamides Q (1) and R (2) showed antimicrobial activity.
Volume 11(8)
Pages 1785-8
Published 2009-4-16
DOI 10.1021/ol900328c
PMID 19296638
MeSH Agelas / chemistry* Alkaloids / chemistry Alkaloids / isolation & purification* Alkaloids / pharmacology Animals Aspergillus niger / drug effects Bacillus subtilis / drug effects Candida albicans / drug effects Cryptococcus neoformans / drug effects Escherichia coli / drug effects Imidazoles / chemistry Imidazoles / isolation & purification* Imidazoles / pharmacology Microbial Sensitivity Tests Micrococcus luteus / drug effects Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pyrroles / chemistry Pyrroles / isolation & purification* Pyrroles / pharmacology Staphylococcus aureus / drug effects Trichophyton / drug effects
IF 6.091
Times Cited 34
Pathogenic microorganisms NA