RRC ID 47009
Author Mukai A, Fukai T, Hoshino Y, Yazawa K, Harada K, Mikami Y.
Title Nocardithiocin, a novel thiopeptide antibiotic, produced by pathogenic Nocardia pseudobrasiliensis IFM 0757.
Journal J. Antibiot.
Abstract Nocardithiocin is a novel thiopeptide compound produced by the pathogenic Nocardia pseudobrasiliensis strain IFM 0757. It shows a strong activity against acid-fast bacilli such as the Mycobacterium and Gordonia species. Nocardithiocin was highly active against rifampicin-resistant as well as -sensitive Mycobacterium tuberculosis strains, and most of the resistant strains were inhibited at concentrations ranging from 0.025 to 1.56 microg ml(-1). The structure of the thiopeptide antibiotic containing thiazole, natural and unnatural amino acids was elucidated by MS and NMR spectral analyses.
Volume 62(11)
Pages 613-9
Published 2009-11
DOI 10.1038/ja.2009.90
PII ja200990
PMID 19745839
MeSH Anti-Bacterial Agents / chemistry Anti-Bacterial Agents / isolation & purification* Anti-Bacterial Agents / pharmacology Fermentation Magnetic Resonance Spectroscopy Nocardia / metabolism* Peptides, Cyclic / chemistry Peptides, Cyclic / isolation & purification* Peptides, Cyclic / pharmacology Stereoisomerism Thiazoles / chemistry Thiazoles / isolation & purification* Thiazoles / pharmacology
IF 2.033
Times Cited 22
WOS Category PHARMACOLOGY & PHARMACY BIOTECHNOLOGY & APPLIED MICROBIOLOGY MICROBIOLOGY IMMUNOLOGY
Resource
Pathogenic microorganisms IFM 0757 IFM 2057