論文 - 詳細
| RRC ID | 47042 |
|---|---|
| 著者 | Oarada M, Tsuzuki T, Gonoi T, Igarashi M, Kamei K, Nikawa T, Hirasaka K, Ogawa T, Miyazawa T, Nakagawa K, Kurita N. |
| タイトル | Effects of dietary fish oil on lipid peroxidation and serum triacylglycerol levels in psychologically stressed mice. |
| ジャーナル | Nutrition |
| Abstract |
OBJECTIVE:The intake of omega-3 polyunsaturated fatty acids and psychological stress can each induce tissue lipid peroxidation. In our present study, we investigated their combined effects on the oxidative status of mouse tissues. METHODS:Mice were group-housed (four mice/cage) and fed a diet containing fish oil (as a source of omega-3 polyunsaturated fatty acids), soybean oil, or olive oil for 3 wk. These animals were then 1) housed under the same conditions (four per cage, control group) or 2) individually housed to generate psychological stress conditions (isolation stress). After 2 wk of isolation stress, the levels of thiobarbituric acid-reactive substances (an index of lipid peroxidation) and antioxidants in the liver and kidney and the serum levels of triacylglycerol were measured. RESULTS:Fish oil-fed mice showed increased levels of thiobarbituric acid-reactive substances in their livers and kidneys compared with soybean oil- or olive oil-fed mice. These increases in thiobarbituric acid-reactive substance levels in the fish oil-fed mice were less profound under isolation stress conditions when compared with the group-housed animals on the same diet. In the fish oil-fed mice, isolation stress led to an increase in liver vitamin E levels when compared with their group-housed counterparts. The fish oil-fed mice exhibited lower serum triacylglycerol levels compared with the soybean oil- or olive oil-fed mice, and this decrease was more profound under conditions of isolation stress when compared with group-housing conditions. CONCLUSION:Dietary fish oil combined with isolation stress results in lower levels of lipid peroxidation in the liver and kidney compared with dietary fish oil alone. |
| 巻・号 | 24(1) |
| ページ | 67-75 |
| 公開日 | 2008-1-1 |
| DOI | 10.1016/j.nut.2007.10.006 |
| PII | S0899-9007(07)00312-7 |
| PMID | 18070659 |
| MeSH | Animals Antioxidants / analysis Antioxidants / metabolism Fatty Acids, Omega-3 / administration & dosage Fatty Acids, Omega-3 / pharmacology Female Fish Oils / administration & dosage Fish Oils / pharmacology* Kidney / drug effects Kidney / metabolism Lipid Peroxidation / drug effects* Liver / drug effects Liver / metabolism Mice Mice, Inbred BALB C Olive Oil Oxidative Stress / drug effects Plant Oils Random Allocation Soybean Oil Stress, Psychological* Thiobarbituric Acid Reactive Substances / analysis* Thiobarbituric Acid Reactive Substances / metabolism Triglycerides / blood* |
| IF | 3.639 |
| 引用数 | 25 |
| WOS 分野 | NUTRITION & DIETETICS |
| リソース情報 | |
| 病原微生物 | NA |