論文 - 詳細
| RRC ID | 47072 |
|---|---|
| 著者 | Shen YC, Cheng YB, Kobayashi J, Kubota T, Takahashi Y, Mikami Y, Ito J, Lin YS. |
| タイトル | Nitrogen-containing verticillene diterpenoids from the Taiwanese soft coral Cespitularia taeniata. |
| ジャーナル | J Nat Prod |
| Abstract |
Extensive column chromatography of the ethanolic extract of the soft coral Cespitularia taeniata collected in Taiwan has resulted in the isolation of eight new nitrogen-containing verticillene diterpenes, designated cespitulactams D-K ( 1- 8), together with three known diterpenes, cespitulactams A ( 9) and B ( 10) and cespitularin F. In addition, one new derivative, 6- O-acetylcespitulactam F ( 11), was prepared from compound 3. The structures of these compounds were elucidated on the basis of spectroscopic analyses, especially HRMS and 2D NMR experiments. The cytotoxicity against human oral epidermoid carcinoma (KB) and murine L1210 leukemia cell lines and antimicrobial activities of 1- 8 and 11 were tested and evaluated. A biogenetic pathway for these novel diterpene alkaloids was also proposed. |
| 巻・号 | 70(12) |
| ページ | 1961-5 |
| 公開日 | 2007-12-1 |
| DOI | 10.1021/np078011u |
| PMID | 18052327 |
| MeSH | Animals Anthozoa / chemistry* Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification* Antineoplastic Agents / pharmacology Diterpenes / chemistry Diterpenes / isolation & purification* Diterpenes / pharmacology Drug Screening Assays, Antitumor Humans Indole Alkaloids / chemistry Indole Alkaloids / isolation & purification* Indole Alkaloids / pharmacology Mice Models, Molecular Molecular Conformation Molecular Structure Nitrogen / chemistry* Taiwan |
| IF | 3.782 |
| 引用数 | 19 |
| WOS 分野 | PLANT SCIENCES PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| リソース情報 | |
| 病原微生物 | |