論文 - 詳細
| RRC ID | 47281 |
|---|---|
| 著者 | Imai KS, Hikawa H, Kobayashi K, Satou Y. |
| タイトル | Tfap2 and Sox1/2/3 cooperatively specify ectodermal fates in ascidian embryos. |
| ジャーナル | Development |
| Abstract |
Epidermis and neural tissues differentiate from the ectoderm in animal embryos. Although epidermal fate is thought to be induced in vertebrate embryos, embryological evidence has indicated that no intercellular interactions during early stages are required for epidermal fate in ascidian embryos. To test this hypothesis, we determined the gene regulatory circuits for epidermal and neural specification in the ascidian embryo. These circuits started with Tfap2-r.b and Sox1/2/3, which are expressed in the ectodermal lineage immediately after zygotic genome activation. Tfap2-r.b expression was diminished in the neural lineages upon activation of fibroblast growth factor signaling, which is known to induce neural fate, and sustained only in the epidermal lineage. Tfap2-r.b specified the epidermal fate cooperatively with Dlx.b, which was activated by Sox1/2/3 This Sox1/2/3-Dlx.b circuit was also required for specification of the anterior neural fate. In the posterior neural lineage, Sox1/2/3 activated Nodal, which is required for specification of the posterior neural fate. Our findings support the hypothesis that the epidermal fate is specified autonomously in ascidian embryos. |
| 巻・号 | 144(1) |
| ページ | 33-37 |
| 公開日 | 2017-1-1 |
| DOI | 10.1242/dev.142109 |
| PII | dev.142109 |
| PMID | 27888190 |
| MeSH | Animals Animals, Genetically Modified Body Patterning / genetics Cell Differentiation / genetics Cell Lineage / genetics Ciona intestinalis / embryology* Ciona intestinalis / genetics Ectoderm / embryology* Ectoderm / metabolism Embryo, Nonmammalian Epidermis / embryology Epidermis / metabolism Gene Expression Regulation, Developmental SOXB1 Transcription Factors / physiology* Signal Transduction / genetics Transcription Factor AP-2 / physiology* Urochordata / embryology* Urochordata / genetics |
| IF | 5.611 |
| 引用数 | 7 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| カタユウレイボヤ・(ニッポンウミシダ) | Wild C. int |