論文 - 詳細
| RRC ID | 4733 |
|---|---|
| 著者 | Shuaibu MN, Wuyep PT, Yanagi T, Hirayama K, Ichinose A, Tanaka T, Kouno I. |
| タイトル | Trypanocidal activity of extracts and compounds from the stem bark of Anogeissus leiocarpus and Terminalia avicennoides. |
| ジャーナル | Parasitol Res |
| Abstract |
The antitrypanosomal activity of methanolic extracts of Anogeissus leiocarpus and Terminalia avicennoides were evaluated in vitro against four strains of Trypanosoma species with minimum inhibitory concentration (MIC) value range of 12.5-50 mg/ml. Successive fractionations of the two plant extracts in water, butanol and ethyl acetate gave a range of activity (MIC, 20 to > or =50 microg/ml). Activity-guided and chromatographic analysis of butanolic fractions on Sephadex LH-20 column followed by high-performance liquid chromatography, nuclear magnetic resonance analysis and both ultraviolet and thin layer chromatography revealed hydrolysable tannins with a range of activity (MIC, 7.5-27.5 microg/ml or 14-91 microM). Effect of the compounds on fibroblasts did not reveal serious toxicity at moderate concentration but is concentration dependent. |
| 巻・号 | 102(4) |
| ページ | 697-703 |
| 公開日 | 2008-3-1 |
| DOI | 10.1007/s00436-007-0815-1 |
| PMID | 18066599 |
| MeSH | Animals Brain / cytology Brain / drug effects Cells, Cultured Combretaceae / chemistry* Fibroblasts / drug effects Medicine, African Traditional Mice Parasitic Sensitivity Tests Plant Bark / chemistry Plant Extracts / chemistry Plant Extracts / pharmacology* Plant Extracts / toxicity Plant Stems / chemistry Plants, Medicinal / chemistry Terminalia / chemistry* Trypanocidal Agents / chemistry Trypanocidal Agents / pharmacology* Trypanocidal Agents / toxicity Trypanosoma / classification Trypanosoma / drug effects* |
| IF | 1.641 |
| 引用数 | 37 |
| WOS 分野 | PARASITOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 病原微生物 | Trypanosoma brucei brucei Trypanosoma brucei gambiense Trypanosoma brucei rhodesiense Trypanosoma evansi |