| RRC ID |
47626
|
| Author |
Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S.
|
| Title |
A family of metabotropic glutamate receptors.
|
| Journal |
Neuron
|
| Abstract |
Three cDNA clones, mGluR2, mGluR3, and mGluR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is expressed in some particular neuronal cells different from those expressing mGluR1 and mediates an efficient inhibition of forskolin-stimulated cAMP formation in cDNA-transfected cells. The mGluRs thus form a novel family of G protein-coupled receptors that differ in their signal transduction and expression patterns.
|
| Volume |
8(1)
|
| Pages |
169-79
|
| Published |
1992-1-1
|
| DOI |
10.1016/0896-6273(92)90118-w
|
| PII |
0896-6273(92)90118-W
|
| PMID |
1309649
|
| MeSH |
Amino Acid Sequence
Animals
Base Sequence
Brain Chemistry
CHO Cells
Cell Membrane / chemistry
Cerebellum / chemistry
Cerebral Cortex / chemistry
Cloning, Molecular
Colforsin / pharmacology
Cricetinae
Cyclic AMP / biosynthesis
DNA / chemistry
DNA / isolation & purification
Gene Expression
Molecular Sequence Data
Nucleic Acid Hybridization
Olfactory Bulb / chemistry
RNA, Messenger / analysis
Rats
Receptors, Glutamate
Receptors, Neurotransmitter / chemistry
Receptors, Neurotransmitter / genetics*
Signal Transduction
Tissue Distribution
Transfection
|
| IF |
14.415
|
| Times Cited |
941
|
|
WOS Category
|
NEUROSCIENCES
|
| Resource |
| DNA material |
pmGR1 (beta) (RDB13195)
pmGR 2 (RDB13196)
pmGR 3 (RDB13197)
pmGR 4 (RDB13198). |
