論文 - 詳細
| RRC ID | 47627 |
|---|---|
| 著者 | Masu M, Tanabe Y, Tsuchida K, Shigemoto R, Nakanishi S. |
| タイトル | Sequence and expression of a metabotropic glutamate receptor. |
| ジャーナル | Nature |
| Abstract |
The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2-3 and in cerebellar Purkinje cells, suggesting the importance of this receptor in specific hippocampal and cerebellar functions. |
| 巻・号 | 349(6312) |
| ページ | 760-5 |
| 公開日 | 1991-2-28 |
| DOI | 10.1038/349760a0 |
| PMID | 1847995 |
| MeSH | Amino Acid Sequence Animals Base Sequence Cerebellum / metabolism Cloning, Molecular Electrophysiology / methods Female Glutamates / metabolism Glutamates / pharmacology* Models, Structural Molecular Sequence Data Nucleic Acid Hybridization Oocytes / drug effects Oocytes / physiology Protein Conformation RNA, Messenger / analysis RNA, Messenger / genetics Rats Receptors, Glutamate Receptors, Neurotransmitter / drug effects Receptors, Neurotransmitter / genetics* Receptors, Neurotransmitter / physiology Sequence Homology, Nucleic Acid Xenopus |
| IF | 42.779 |
| 引用数 | 1062 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 108 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | pmGR1 (alpha) (RDB13194) |