論文 - 詳細
| RRC ID | 47788 |
|---|---|
| 著者 | Yun HM, Noh S, Hyun S. |
| タイトル | Minocycline treatment suppresses juvenile development and growth by attenuating insulin/TOR signaling in Drosophila animal model. |
| ジャーナル | Sci Rep |
| Abstract |
Minocycline is a broad spectrum, semi-synthetic tetracycline analog that is used to treat bacterial infection. Recently, this drug has been receiving increasing attention for its non-antibiotic properties, including anti-inflammatory, tumor suppressive, and neuroprotective effects. Drosophila is a useful model organism for studying human metabolism and disease. In this study, we investigated the effects of minocycline on juvenile development and growth in Drosophila. Feeding minocycline to Drosophila larvae suppresses larval body growth and delays the timing of pupation in a dose-dependent manner. We found that the drug treatment decreased the activated form of Akt and S6K in peripheral tissues, which suggested that the insulin/target of rapamycin (TOR) signaling had been attenuated. Specifically enhancing TOR activity in the prothoracic gland (PG), the ecdysone-generating organ, attenuated the drug-induced developmental delay, which is consistent with the critical role of PG's TOR signaling in determining pupation time. Our results reveal previously unrecognized effects of minocycline and offer a new potential therapeutic opportunity for various pathological conditions associated with insulin/TOR signaling. |
| 巻・号 | 7 |
| ページ | 44724 |
| 公開日 | 2017-3-20 |
| DOI | 10.1038/srep44724 |
| PII | srep44724 |
| PMID | 28317899 |
| PMC | PMC5357794 |
| MeSH | Animal Structures / drug effects Animals Body Size / drug effects Drosophila Proteins / metabolism* Drosophila melanogaster / anatomy & histology Drosophila melanogaster / drug effects Drosophila melanogaster / growth & development* Drosophila melanogaster / metabolism* Ecdysone / metabolism Feeding Behavior Insulin / metabolism* Larva / drug effects Larva / growth & development Larva / metabolism Minocycline / administration & dosage Minocycline / pharmacology* Models, Animal Pupa / drug effects Pupa / growth & development Signal Transduction* / drug effects TOR Serine-Threonine Kinases / metabolism* |
| IF | 3.998 |
| 引用数 | 2 |
| WOS 分野 | MULTIDISCIPLINARY SCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ショウジョウバエ | 6975R-8 |