RRC ID 48014
Author Chiken S, Nambu A.
Title Mechanism of Deep Brain Stimulation: Inhibition, Excitation, or Disruption?
Journal Neuroscientist
Abstract Deep brain stimulation (DBS), applying high-frequency electrical stimulation to deep brain structures, has now provided an effective therapeutic option for treatment of various neurological and psychiatric disorders. DBS targeting the internal segment of the globus pallidus, subthalamic nucleus, and thalamus is used to treat symptoms of movement disorders, such as Parkinson's disease, dystonia, and tremor. However, the mechanism underlying the beneficial effects of DBS remains poorly understood and is still under debate: Does DBS inhibit or excite local neuronal elements? In this short review, we would like to introduce our recent work on the physiological mechanism of DBS and propose an alternative explanation: DBS dissociates input and output signals, resulting in the disruption of abnormal information flow through the stimulation site.
Volume 22(3)
Pages 313-22
Published 2016-6-1
DOI 10.1177/1073858415581986
PII 1073858415581986
PMID 25888630
PMC PMC4871171
MeSH Action Potentials Animals Basal Ganglia / physiopathology Brain / physiopathology* Cerebral Cortex / physiopathology Deep Brain Stimulation* Humans Models, Neurological* Neural Inhibition* Neural Pathways / physiopathology Neurons / physiology* Parkinson Disease / physiopathology* Parkinson Disease / therapy* Subthalamic Nucleus / physiopathology
IF 6.791
Times Cited 99
WOS Category CLINICAL NEUROLOGY NEUROSCIENCES
Resource
Japanese macaques