RRC ID 48054
Author Watanabe Y, Suga T, Narusawa S, Iwatsuki M, Nonaka K, Nakashima T, Shinohara Y, Shiotsuki T, Ichimaru N, Miyoshi H, Asami Y, Ōmura S, Shiomi K.
Title Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae.
Journal J Antibiot (Tokyo)
Abstract A new decalin, decatamariic acid, was isolated from a cultured broth of the fungus Aspergillus tamarii FKI-6817. Its absolute configuration was elucidated by NMR and electronic circular dichroism. Decatamariic acid (10 μM) elicited ~50% inhibition of the ATP production in mitochondria isolated from wild-type Saccharomyces cerevisiae without affecting the activities of respiratory enzymes. The action manner of this compound may be interesting as a possible seed for new pesticides.
Volume 70(4)
Pages 395-399
Published 2017-4
DOI 10.1038/ja.2016.164
PII ja2016164
PMID 28096549
MeSH Adenosine Triphosphate / antagonists & inhibitors Adenosine Triphosphate / biosynthesis Aspergillus / chemistry Aspergillus / classification Drug Evaluation, Preclinical Fermentation Magnetic Resonance Spectroscopy Mitochondria / drug effects Mitochondria / metabolism* Molecular Conformation Naphthalenes / chemistry* Naphthalenes / pharmacology* Oxygen Consumption / drug effects* Pesticides / chemistry Pesticides / pharmacology* Saccharomyces cerevisiae / drug effects*
IF 2.446
Times Cited 2
WOS Category PHARMACOLOGY & PHARMACY MICROBIOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY IMMUNOLOGY
Resource
Yeast BY25929