論文 - 詳細
| RRC ID | 48054 |
|---|---|
| 著者 | Watanabe Y, Suga T, Narusawa S, Iwatsuki M, Nonaka K, Nakashima T, Shinohara Y, Shiotsuki T, Ichimaru N, Miyoshi H, Asami Y, Ōmura S, Shiomi K. |
| タイトル | Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae. |
| ジャーナル | J Antibiot (Tokyo) |
| Abstract |
A new decalin, decatamariic acid, was isolated from a cultured broth of the fungus Aspergillus tamarii FKI-6817. Its absolute configuration was elucidated by NMR and electronic circular dichroism. Decatamariic acid (10 μM) elicited ~50% inhibition of the ATP production in mitochondria isolated from wild-type Saccharomyces cerevisiae without affecting the activities of respiratory enzymes. The action manner of this compound may be interesting as a possible seed for new pesticides. |
| 巻・号 | 70(4) |
| ページ | 395-399 |
| 公開日 | 2017-4-1 |
| DOI | 10.1038/ja.2016.164 |
| PII | ja2016164 |
| PMID | 28096549 |
| MeSH | Adenosine Triphosphate / antagonists & inhibitors Adenosine Triphosphate / biosynthesis Aspergillus / chemistry Aspergillus / classification Drug Evaluation, Preclinical Fermentation Magnetic Resonance Spectroscopy Mitochondria / drug effects Mitochondria / metabolism* Molecular Conformation Naphthalenes / chemistry* Naphthalenes / pharmacology* Oxygen Consumption / drug effects* Pesticides / chemistry Pesticides / pharmacology* Saccharomyces cerevisiae / drug effects* |
| IF | 2.668 |
| 引用数 | 2 |
| WOS 分野 | PHARMACOLOGY & PHARMACY MICROBIOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY IMMUNOLOGY |
| リソース情報 | |
| 酵母 | BY25929 |