論文 - 詳細
| RRC ID | 48105 |
|---|---|
| 著者 | Arai H, Hori S, Aramori I, Ohkubo H, Nakanishi S. |
| タイトル | Cloning and expression of a cDNA encoding an endothelin receptor. |
| ジャーナル | Nature |
| Abstract |
Endothelins are a newly described peptide family consisting of three peptides (ET-1, ET-2 and ET-3) which are the most potent vasoconstrictive peptides known. They are crucial in the regulation of vascular smooth muscle tone. The diverse functions of endothelins are thought to be mediated by interaction with many different receptors coupled to the inositol phosphate/calcium ion messenger pathway. However, because of the structural resemblance of the three peptides, the presence and nature of multiple endothelin receptors remain to be elucidated. We report here the cloning of a complementary DNA encoding a bovine endothelin receptor, which has a transmembrane topology similar to that of other G protein-coupled receptors and shows specific binding, with the highest selectivity to ET-1 in animal cells transfected with the cloned cDNA. This receptor messenger RNA is widely distributed in the central nervous system and peripheral tissues, particularly in the heart and lung. Our results support the view that there are other receptor subtypes. |
| 巻・号 | 348(6303) |
| ページ | 730-2 |
| 公開日 | 1990-12-20 |
| DOI | 10.1038/348730a0 |
| PMID | 2175396 |
| MeSH | Amino Acid Sequence Animals Base Sequence Cattle Cell Line Cloning, Molecular* DNA / genetics* Endothelins / metabolism Gene Expression* Molecular Sequence Data Nucleic Acid Hybridization RNA, Messenger / analysis RNA, Messenger / genetics Receptors, Cell Surface / genetics* Receptors, Cell Surface / metabolism Receptors, Endothelin Recombinant Proteins / metabolism Sequence Homology, Nucleic Acid Transfection |
| IF | 42.779 |
| 引用数 | 2641 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 77 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| 遺伝子材料 | ETAR (RDB13191) |