Reference - Detail
| RRC ID | 48826 |
|---|---|
| Author | Wakisaka N, Miyasaka N, Koide T, Masuda M, Hiraki-Kajiyama T, Yoshihara Y. |
| Title | An Adenosine Receptor for Olfaction in Fish. |
| Journal | Curr Biol |
| Abstract |
Nucleotides released from food sources into environmental water are supposed to act as feeding cues for many fish species. However, it remains unknown how fish can sensitively detect those nucleotides. Here we discover a novel olfactory mechanism for ATP sensing in zebrafish. Upon entering into the nostril, ATP is efficiently converted into adenosine through enzymatic reactions of two ecto-nucleotidases expressed in the olfactory epithelium. Adenosine subsequently activates a small population of olfactory sensory neurons expressing a novel adenosine receptor A2c that is unique to fishes and amphibians. The information is then transmitted to a single glomerulus in the olfactory bulb and further to four regions in higher olfactory centers. These results provide conclusive evidence for a sophisticated enzyme-linked receptor mechanism underlying detection of ATP as a food-derived attractive odorant linking to foraging behavior that is crucial and common to aquatic lower vertebrates. |
| Volume | 27(10) |
| Pages | 1437-1447.e4 |
| Published | 2017-5-22 |
| DOI | 10.1016/j.cub.2017.04.014 |
| PII | S0960-9822(17)30423-2 |
| PMID | 28502661 |
| MeSH | Adenosine / metabolism Adenosine Triphosphatases / metabolism Adenosine Triphosphate / metabolism* Animals Behavior, Animal Calcium / metabolism Nose / physiology Olfactory Mucosa / cytology Olfactory Mucosa / physiology Olfactory Receptor Neurons / cytology Olfactory Receptor Neurons / physiology* Phylogeny Receptors, Purinergic P1 / metabolism Smell / physiology* Zebrafish / physiology* |
| IF | 9.601 |
| Times Cited | 24 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Resource | |
| Human and Animal Cells | CHO-K1(RCB0285) |
| Zebrafish | Tg(OMP6k:GFP)rw033 Tg(TRPC24.5k:gap-Venus)rw037 Tg(OMP:Gal4FF)rw0320 Tg(UAS:G-CaMP7)rw0322 |