論文 - 詳細
| RRC ID | 48830 |
|---|---|
| 著者 | Riveiro AR, Mariani L, Malmberg E, Amendola PG, Peltonen J, Wong G, Salcini AE. |
| タイトル | JMJD-1.2/PHF8 controls axon guidance by regulating Hedgehog-like signaling. |
| ジャーナル | Development |
| Abstract |
Components of the KDM7 family of histone demethylases are implicated in neuronal development and one member, PHF8, is often found to be mutated in cases of X-linked mental retardation. However, how PHF8 regulates neurodevelopmental processes and contributes to the disease is still largely unknown. Here, we show that the catalytic activity of a PHF8 homolog in Caenorhabditis elegans, JMJD-1.2, is required non-cell-autonomously for proper axon guidance. Loss of JMJD-1.2 dysregulates transcription of the Hedgehog-related genes wrt-8 and grl-16, the overexpression of which is sufficient to induce the axonal defects. Deficiency of either wrt-8 or grl-16, or reduced expression of homologs of genes promoting Hedgehog signaling, restores correct axon guidance in jmjd-1.2 mutants. Genetic and overexpression data indicate that Hedgehog-related genes act on axon guidance through actin remodelers. Thus, our study highlights a novel function of jmjd-1.2 in axon guidance that might be relevant for the onset of X-linked mental retardation and provides compelling evidence of a conserved function of the Hedgehog pathway in C. elegans axon migration. |
| 巻・号 | 144(5) |
| ページ | 856-865 |
| 公開日 | 2017-3-1 |
| DOI | 10.1242/dev.142695 |
| PII | dev.142695 |
| PMID | 28126843 |
| MeSH | Actins / metabolism Animals Animals, Genetically Modified Axon Guidance* Axons / metabolism* CRISPR-Cas Systems Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism* Disease Models, Animal Epigenesis, Genetic Gene Expression Regulation, Developmental* Hedgehog Proteins / metabolism* Histone Demethylases / metabolism Jumonji Domain-Containing Histone Demethylases / metabolism* Neurons / metabolism RNA Interference Signal Transduction |
| IF | 5.611 |
| 引用数 | 7 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3713 |